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Bat3 is an adaptor protein that binds to the tail of Tim-3; therefore, we studied its role in regulating the functional status of DCs. In murine models of autoimmunity (experimental autoimmune encephalomyelitis) and cancer (MC38-OVA\u2013implanted tumor), lack of Bat3 expression in DCs alters the T cell compartment\u2014it decreases T\n                    <jats:sub>H<\/jats:sub>\n                    1, T\n                    <jats:sub>H<\/jats:sub>\n                    17 and cytotoxic effector cells, increases regulatory T cells, and exhausted CD8\n                    <jats:sup>+<\/jats:sup>\n                    tumor-infiltrating lymphocytes, resulting in the attenuation of autoimmunity and acceleration of tumor growth. We found that Bat3 expression levels were differentially regulated by activating versus inhibitory stimuli in DCs, indicating a role for Bat3 in the functional calibration of DC phenotypes. Mechanistically, loss of Bat3 in DCs led to hyperactive unfolded protein response and redirected acetyl\u2013coenzyme A to increase cell intrinsic steroidogenesis. The enhanced steroidogenesis in Bat3-deficient DC suppressed T cell response in a paracrine manner. Our findings identified Bat3 as an endogenous regulator of DC function, which has implications for DC-based immunotherapies.\n                  <\/jats:p>","DOI":"10.1126\/sciimmunol.abm0631","type":"journal-article","created":{"date-parts":[[2022,3,11]],"date-time":"2022-03-11T13:59:13Z","timestamp":1647007153000},"source":"Crossref","is-referenced-by-count":51,"title":["Tim-3 adapter protein Bat3 acts as an endogenous regulator of tolerogenic dendritic cell function"],"prefix":"10.1126","volume":"7","author":[{"given":"Ruihan","family":"Tang","sequence":"first","affiliation":[{"name":"Evergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women\u2019s Hospital, Boston, MA, USA."},{"name":"Ann Romney Center for Neurologic Diseases, Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nandini","family":"Acharya","sequence":"additional","affiliation":[{"name":"Evergrande 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