{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T19:46:57Z","timestamp":1787168817376,"version":"build-2736575974"},"reference-count":57,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"76","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sci. Immunol."],"published-print":{"date-parts":[[2022,10,28]]},"abstract":"<jats:p>\n                    Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by inflammation of various organs such as skin, kidneys, bones, and brain and the presence of autoantibodies. Although the cause of SLE is not completely understood, environmental factors, genetic susceptibility, hormone factors, and environmental factors are thought to play essential roles in the pathogenesis of SLE. Among environmental factors, the microbiota are linked to the development of different autoimmune diseases. The microbiota in the nasal cavity and gut are involved in SLE development, but the influence of skin microbiota is still unclear. Here, we demonstrated that epithelial cell\u2013specific I\u03baB\u03b6-deficient (\n                    <jats:italic>Nfkbiz<\/jats:italic>\n                    <jats:sup>\u0394K5<\/jats:sup>\n                    ) mice showed spontaneous skin inflammation with increased abundance of\n                    <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    on the skin. When\n                    <jats:italic>S. aureus<\/jats:italic>\n                    was epicutaneously applied on\n                    <jats:italic>Nfkbiz<\/jats:italic>\n                    <jats:sup>\u0394K5<\/jats:sup>\n                    mice,\n                    <jats:italic>Nfkbiz<\/jats:italic>\n                    <jats:sup>\u0394K5<\/jats:sup>\n                    mice developed SLE-associated autoantibodies, anti-dsDNA antibodies, anti-Sm antibodies, and glomerulonephritis with IgG deposition. Epicutaneous\n                    <jats:italic>S. aureus<\/jats:italic>\n                    application significantly increased staphylococcal colonization on the skin of\n                    <jats:italic>Nfkbiz<\/jats:italic>\n                    <jats:sup>\u0394K5<\/jats:sup>\n                    mice with reduced expression of several antimicrobial peptides in the skin. This staphylococcal skin colonization promoted caspase-mediated keratinocyte apoptosis and neutrophil activation, inducing the interleukin-23 (IL-23)\/IL-17 immune response by activating dendritic cells and T cells. Furthermore, the subcutaneous administration of anti\u2013IL-23p19 and anti\u2013IL-17A antibodies alleviated the systemic autoimmune response. Together, these findings underscore epithelial-immune cross-talk disturbances caused by skin dysbiosis as an essential mediator inducing autoimmune diseases.\n                  <\/jats:p>","DOI":"10.1126\/sciimmunol.abm9811","type":"journal-article","created":{"date-parts":[[2022,10,28]],"date-time":"2022-10-28T13:58:11Z","timestamp":1666965491000},"source":"Crossref","is-referenced-by-count":66,"title":["<i>Staphylococcus aureus<\/i>\n                    skin colonization promotes SLE-like autoimmune inflammation via neutrophil activation and the IL-23\/IL-17 axis"],"prefix":"10.1126","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7598-2833","authenticated-orcid":true,"given":"Hitoshi","family":"Terui","sequence":"first","affiliation":[{"name":"Department of Dermatology, Tohoku University Graduate School of Medicine, Sendai, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5495-4956","authenticated-orcid":true,"given":"Kenshi","family":"Yamasaki","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Tohoku University Graduate School of Medicine, Sendai, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3908-4339","authenticated-orcid":true,"given":"Moyuka","family":"Wada-Irimada","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Tohoku University Graduate School of Medicine, Sendai, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8243-8537","authenticated-orcid":true,"given":"Mayuko","family":"Onodera-Amagai","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Tohoku University Graduate School of Medicine, Sendai, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8551-2184","authenticated-orcid":true,"given":"Naokazu","family":"Hatchome","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Tohoku University Graduate School of Medicine, Sendai, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0977-4443","authenticated-orcid":true,"given":"Masato","family":"Mizuashi","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Tohoku University Graduate School of Medicine, Sendai, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riu","family":"Yamashita","sequence":"additional","affiliation":[{"name":"Division of Translational Informatics, Exploratory Oncology Research &amp; Clinical Trial Center, National Cancer Center, Kashiwa, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7173-4472","authenticated-orcid":true,"given":"Takeshi","family":"Kawabe","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Tohoku University Graduate School of Medicine, Sendai, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0549-8245","authenticated-orcid":true,"given":"Naoto","family":"Ishii","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Tohoku University Graduate School of Medicine, Sendai, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3170-4660","authenticated-orcid":true,"given":"Takaaki","family":"Abe","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Endocrinology, and Vascular Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan."},{"name":"Division of Medical Science, Tohoku University Graduate School of Biomedical Engineering, Sendai, Japan."},{"name":"Department of Clinical Biology and Hormonal Regulation, Tohoku University Graduate School of Medicine, Sendai, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5560-9778","authenticated-orcid":true,"given":"Yoshihide","family":"Asano","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Tohoku University Graduate School of Medicine, Sendai, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Setsuya","family":"Aiba","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Tohoku University Graduate School of Medicine, Sendai, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aar7201"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2634-9"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2018-214856"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1101\/gr.131029.111"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2015.03.014"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2019.11.016"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph110808112"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1177\/0961203314543920"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00476-2019"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature02738"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2012.11.016"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms8001"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1856-1"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1844-5"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2016.04.012"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1801377115"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.130835"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/exd.13314"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-05740-z"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1225152"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature14052"},{"key":"e_1_3_3_23_2","first-page":"298506","article-title":"Association between secondary and primary Sj\u00f6gren\u2019s Syndrome in a large collection of lupus families","volume":"2015","author":"Aggarwal R.","year":"2015","unstructured":"R.\u00a0Aggarwal, J. 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