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Eosinophil regulation of thymus regeneration occurs via the concerted action of NKT cells that trigger CCL11 production via IL4 receptor signaling in thymic stroma, and ILC2 that represent an intrathymic source of IL5, a cytokine that therapeutically boosts thymus regeneration after damage. Collectively, our findings identify an intrathymic network composed of multiple innate immune cells that restores thymus function during reestablishment of the adaptive immune system.<\/jats:p>","DOI":"10.1126\/sciimmunol.abn3286","type":"journal-article","created":{"date-parts":[[2022,3,11]],"date-time":"2022-03-11T18:59:13Z","timestamp":1647025153000},"source":"Crossref","is-referenced-by-count":68,"title":["Eosinophils are an essential element of a type 2 immune axis that controls thymus regeneration"],"prefix":"10.1126","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7207-2511","authenticated-orcid":true,"given":"Emilie J.","family":"Cosway","sequence":"first","affiliation":[{"name":"Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea J.","family":"White","sequence":"additional","affiliation":[{"name":"Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4430-9072","authenticated-orcid":true,"given":"Sonia M.","family":"Parnell","sequence":"additional","affiliation":[{"name":"Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9421-6763","authenticated-orcid":true,"given":"Edina","family":"Schweighoffer","sequence":"additional","affiliation":[{"name":"Francis Crick Institute, London NW1 1AT, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen E.","family":"Jolin","sequence":"additional","affiliation":[{"name":"MRC Laboratory of Molecular Biology, Cambridge, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2688-8952","authenticated-orcid":true,"given":"Andrea","family":"Bacon","sequence":"additional","affiliation":[{"name":"Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans-Reimer","family":"Rodewald","sequence":"additional","affiliation":[{"name":"Division of Cellular Immunology, German Cancer Research Center, 69120 Heidelberg, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2439-0798","authenticated-orcid":true,"given":"Victor","family":"Tybulewicz","sequence":"additional","affiliation":[{"name":"Francis Crick Institute, London NW1 1AT, UK."},{"name":"Department of Immunology and Inflammation, Imperial College London, London W12 0NN, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9757-2512","authenticated-orcid":true,"given":"Andrew N. 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