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Furthermore, experiments using genetically modified mice with specific deletions in the<jats:italic>Foxn1<\/jats:italic>locus and additional bioinformatic analyses helped us identify key regions and transcription factors involved in either positive or negative regulation of<jats:italic>Foxn1<\/jats:italic>in both TECs and HFCs. Specifically, we identified SIX1 and FOXN1 itself as key factors inducing<jats:italic>Foxn1<\/jats:italic>expression in embryonic and neonatal TECs. 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