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We showed that the predominant mouse subset, which produced IL-17 (MAIT17), and the subset that produced IFN-\u03b3 (MAIT1) had not only greatly different transcriptomes but also different metabolic states. MAIT17 cells in different organs exhibited increased lipid uptake, lipid storage, and mitochondrial potential compared with MAIT1 cells. All these properties were similar in the thymus and likely acquired there. Human MAIT cells in lung and blood were more homogeneous but still differed between tissues. Human MAIT cells had increased fatty acid uptake and lipid storage in blood and lung, similar to human CD8 T resident memory cells, but unlike mouse MAIT17 cells, they lacked increased mitochondrial potential. Although mouse and human MAIT cell transcriptomes showed similarities for immature cells in the thymus, they diverged more strikingly in the periphery. Analysis of pet store mice demonstrated decreased lung MAIT17 cells in these so-called \u201cdirty\u201d mice, indicative of an environmental influence on MAIT cell subsets and function.<\/jats:p>","DOI":"10.1126\/sciimmunol.abn8531","type":"journal-article","created":{"date-parts":[[2023,11,10]],"date-time":"2023-11-10T13:58:20Z","timestamp":1699624700000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":59,"title":["Transcriptomes and metabolism define mouse and human MAIT cell populations"],"prefix":"10.1126","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6814-1198","authenticated-orcid":true,"given":"Shilpi","family":"Chandra","sequence":"first","affiliation":[{"name":"Center for Autoimmunity and Inflammation, La Jolla Institute for Immunology, La Jolla, CA 92037, USA."},{"name":"Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, CA 92037, 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