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Mechanistically, ICT induces lymph node remodeling and dendritic cell (DC) activation, which facilitates the translocation of a selective subset of gut bacteria to extraintestinal tissues to promote optimal antitumor T cell responses in both the tumor-draining lymph nodes (TDLNs) and the primary tumor. Antibiotic treatment results in decreased gut microbiota translocation into mesenteric lymph nodes (MLNs) and TDLNs, diminished DC and effector CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cell responses, and attenuated responses to ICT. Our findings illuminate a key mechanism by which gut microbiota promote extraintestinal anticancer immunity.\n                  <\/jats:p>","DOI":"10.1126\/sciimmunol.abo2003","type":"journal-article","created":{"date-parts":[[2023,3,3]],"date-time":"2023-03-03T13:58:18Z","timestamp":1677851898000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":135,"title":["Immune checkpoint blockade induces gut microbiota translocation that augments extraintestinal antitumor immunity"],"prefix":"10.1126","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0329-3895","authenticated-orcid":true,"given":"Yongbin","family":"Choi","sequence":"first","affiliation":[{"name":"Division of Hematology\/Oncology, Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA."},{"name":"Department of Immunology, University of Texas Southwestern Medical Center, Dallas, TX 75390, 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