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BA.1 breakthrough infection induced a robust recall response, primarily expanding memory B (B\n                    <jats:sub>MEM<\/jats:sub>\n                    ) cells against epitopes shared broadly among variants, rather than inducing BA.1-specific B cells. The vaccination-imprinted B\n                    <jats:sub>MEM<\/jats:sub>\n                    cell pool had sufficient plasticity to be remodeled by heterologous SARS-CoV-2 spike glycoprotein exposure. Whereas selective amplification of B\n                    <jats:sub>MEM<\/jats:sub>\n                    cells recognizing shared epitopes allows for effective neutralization of most variants that evade previously established immunity, susceptibility to escape by variants that acquire alterations at hitherto conserved sites may be heightened.\n                  <\/jats:p>","DOI":"10.1126\/sciimmunol.abq2427","type":"journal-article","created":{"date-parts":[[2022,6,2]],"date-time":"2022-06-02T13:58:06Z","timestamp":1654178286000},"source":"Crossref","is-referenced-by-count":213,"title":["Omicron BA.1 breakthrough infection drives cross-variant neutralization and memory B cell formation against conserved epitopes"],"prefix":"10.1126","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9589-9941","authenticated-orcid":true,"given":"Jasmin","family":"Quandt","sequence":"first","affiliation":[{"name":"BioNTech, An der Goldgrube 12, 55131 Mainz, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4561-2273","authenticated-orcid":true,"given":"Alexander","family":"Muik","sequence":"additional","affiliation":[{"name":"BioNTech, An der Goldgrube 12, 55131 Mainz, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadine","family":"Salisch","sequence":"additional","affiliation":[{"name":"BioNTech, An der Goldgrube 12, 55131 Mainz, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8260-5075","authenticated-orcid":true,"given":"Bonny Gaby","family":"Lui","sequence":"additional","affiliation":[{"name":"BioNTech, An der Goldgrube 12, 55131 Mainz, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8415-6437","authenticated-orcid":true,"given":"Sebastian","family":"Lutz","sequence":"additional","affiliation":[{"name":"BioNTech, An der Goldgrube 12, 55131 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