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In mice, we found that circulating memory T cells were dispensable for anamnestic protection from\n            <jats:italic>Candida albicans<\/jats:italic>\n            skin infection, and tissue-resident memory (T\n            <jats:sub>RM<\/jats:sub>\n            ) cell\u2013mediated protection from\n            <jats:italic>C. albicans<\/jats:italic>\n            reinfection required IL-23. Administration of anti\u2013IL-23 receptor antibody to mice after resolution of primary\n            <jats:italic>C. albicans<\/jats:italic>\n            infection resulted in loss of CD69\n            <jats:sup>+<\/jats:sup>\n            CD103\n            <jats:sup>+<\/jats:sup>\n            tissue-resident memory T helper 17 (T\n            <jats:sub>RM17<\/jats:sub>\n            ) cells from skin, and clinical anti\u2013IL-23 therapy depleted T\n            <jats:sub>RM17<\/jats:sub>\n            cells from skin of patients with psoriasis. IL-23 receptor blockade impaired T\n            <jats:sub>RM17<\/jats:sub>\n            cell proliferation but did not affect apoptosis susceptibility or tissue egress. IL-23 produced by CD301b\n            <jats:sup>+<\/jats:sup>\n            myeloid cells was required for T\n            <jats:sub>RM17<\/jats:sub>\n            maintenance in skin after\n            <jats:italic>C. albicans<\/jats:italic>\n            infection, and CD301b\n            <jats:sup>+<\/jats:sup>\n            cells were necessary for T\n            <jats:sub>RM17<\/jats:sub>\n            expansion during the development of imiquimod dermatitis. This study demonstrates that locally produced IL-23 promotes in situ proliferation of cutaneous T\n            <jats:sub>RM17<\/jats:sub>\n            cells to support their longevity and function and provides mechanistic insight into the durable efficacy of IL-23 blockade in the treatment of psoriasis.\n          <\/jats:p>","DOI":"10.1126\/sciimmunol.abq3254","type":"journal-article","created":{"date-parts":[[2022,11,11]],"date-time":"2022-11-11T18:58:08Z","timestamp":1668193088000},"source":"Crossref","is-referenced-by-count":130,"title":["Local IL-23 is required for proliferation and retention of skin-resident memory T\n            <sub>H<\/sub>\n            17 cells"],"prefix":"10.1126","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0508-5918","authenticated-orcid":true,"given":"Sarah K.","family":"Whitley","sequence":"first","affiliation":[{"name":"Department of Dermatology, University of Pittsburgh, Pittsburgh, PA, 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K.","family":"Ferris","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University of Pittsburgh, Pittsburgh, PA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2180-1793","authenticated-orcid":true,"given":"Casey T.","family":"Weaver","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Alabama at Birmingham, Birmingham, AL, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel J.","family":"Cua","sequence":"additional","affiliation":[{"name":"Janssen Research and Development, Spring House, PA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mandy J.","family":"McGeachy","sequence":"additional","affiliation":[{"name":"Department of Immunology, University of Pittsburgh, Pittsburgh, PA, USA."},{"name":"Division of Rheumatology and Clinical Immunology, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, 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