{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T17:00:07Z","timestamp":1791478807197,"version":"4.3.4"},"reference-count":94,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"80","content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Sci. Immunol."],"published-print":{"date-parts":[[2023,2,3]]},"abstract":"<jats:p>\n            Patients with autosomal recessive (AR) IL-12p40 or IL-12R\u03b21 deficiency display Mendelian susceptibility to mycobacterial disease (MSMD) due to impaired IFN-\u03b3 production and, less commonly, chronic mucocutaneous candidiasis (CMC) due to impaired IL-17A\/F production. We report six patients from four kindreds with AR IL-23R deficiency. These patients are homozygous for one of four different loss-of-function\n            <jats:italic>IL23R<\/jats:italic>\n            variants. All six patients have a history of MSMD, but only two suffered from CMC. We show that IL-23 induces IL-17A only in MAIT cells, possibly contributing to the incomplete penetrance of CMC in patients unresponsive to IL-23. By contrast, IL-23 is required for both baseline and\n            <jats:italic>Mycobacterium<\/jats:italic>\n            -inducible IFN-\u03b3 immunity in both V\u03b42\n            <jats:sup>+<\/jats:sup>\n            \u03b3\u03b4 T and MAIT cells, probably contributing to the higher penetrance of MSMD in these patients. Human IL-23 appears to contribute to IL-17A\/F\u2013dependent immunity to\n            <jats:italic>Candida<\/jats:italic>\n            in a single lymphocyte subset but is required for IFN-\u03b3\u2013dependent immunity to\n            <jats:italic>Mycobacterium<\/jats:italic>\n            in at least two lymphocyte subsets.\n          <\/jats:p>","DOI":"10.1126\/sciimmunol.abq5204","type":"journal-article","created":{"date-parts":[[2023,2,10]],"date-time":"2023-02-10T18:58:21Z","timestamp":1676055501000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":79,"title":["Human IL-23 is essential for IFN-\u03b3\u2013dependent immunity to mycobacteria"],"prefix":"10.1126","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3429-9605","authenticated-orcid":true,"given":"Quentin","family":"Philippot","sequence":"first","affiliation":[{"name":"Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM) U1163, Necker Hospital for Sick Children, Paris, France."},{"name":"University Paris Cit\u00e9, Imagine Institute, Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2421-7389","authenticated-orcid":true,"given":"Masato","family":"Ogishi","sequence":"additional","affiliation":[{"name":"St.\u00a0Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University, New\u00a0York, NY, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0458-9484","authenticated-orcid":true,"given":"Jonathan","family":"Bohlen","sequence":"additional","affiliation":[{"name":"Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM) U1163, Necker Hospital for Sick Children, Paris, France."},{"name":"University Paris Cit\u00e9, Imagine Institute, Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0284-3629","authenticated-orcid":true,"given":"Julia","family":"Puchan","sequence":"additional","affiliation":[{"name":"Institute of Microbiology, ETH Z\u00fcrich, Z\u00fcrich, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9478-8403","authenticated-orcid":true,"given":"Andr\u00e9s Augusto","family":"Arias","sequence":"additional","affiliation":[{"name":"St.\u00a0Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University, New\u00a0York, NY, USA."},{"name":"Primary Immunodeficiencies Group, University of Antioquia (UdeA), Medellin, Colombia."},{"name":"School of Microbiology, University of Antioquia (UdeA), Medellin, Colombia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0709-3636","authenticated-orcid":true,"given":"Tina","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Garvan Institute of Medical Research, Darlinghurst, NSW, Australia."},{"name":"School of Clinical Medicine, Faculty of Medicine and Health, UNSW Sydney, Sydney, NSW, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4671-6349","authenticated-orcid":true,"given":"Marta","family":"Martin-Fernandez","sequence":"additional","affiliation":[{"name":"Center for Inborn Errors of Immunity, Icahn School of Medicine at Mount Sinai, New\u00a0York, NY, USA."},{"name":"Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New\u00a0York, NY, USA."},{"name":"Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New\u00a0York, NY, USA."},{"name":"Department of Pediatrics, Icahn School of Medicine at Mount Sinai, New\u00a0York, NY, USA."},{"name":"Department of Microbiology, Icahn School of Medicine at Mount Sinai, New\u00a0York, NY, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clement","family":"Conil","sequence":"additional","affiliation":[{"name":"Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM) U1163, Necker Hospital for Sick Children, Paris, France."},{"name":"University Paris Cit\u00e9, Imagine Institute, Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8851-7730","authenticated-orcid":true,"given":"Darawan","family":"Rinchai","sequence":"additional","affiliation":[{"name":"St.\u00a0Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University, New\u00a0York, NY, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5340-2762","authenticated-orcid":true,"given":"Mana","family":"Momenilandi","sequence":"additional","affiliation":[{"name":"Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM) U1163, Necker Hospital for Sick Children, Paris, France."},{"name":"University Paris Cit\u00e9, Imagine Institute, Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6224-4797","authenticated-orcid":true,"given":"Seyed Alireza","family":"Mahdaviani","sequence":"additional","affiliation":[{"name":"Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4494-6220","authenticated-orcid":true,"given":"Mohammad","family":"Keramatipour","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2822-161X","authenticated-orcid":true,"given":"J\u00e9r\u00e9mie","family":"Rosain","sequence":"additional","affiliation":[{"name":"Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM) U1163, Necker Hospital for Sick Children, Paris, France."},{"name":"University Paris Cit\u00e9, Imagine Institute, Paris, 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USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Peel","sequence":"additional","affiliation":[{"name":"St.\u00a0Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University, New\u00a0York, NY, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0455-4687","authenticated-orcid":true,"given":"Federico","family":"Mele","sequence":"additional","affiliation":[{"name":"Institute for Research in Biomedicine, Universit\u00e0 della Svizzera italiana, Bellinzona, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7769-1730","authenticated-orcid":true,"given":"Marc","family":"Weisshaar","sequence":"additional","affiliation":[{"name":"Institute of Microbiology, ETH Z\u00fcrich, Z\u00fcrich, 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Paris, France."},{"name":"University Paris Cit\u00e9, Imagine Institute, Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7404-0860","authenticated-orcid":true,"given":"Carlos A.","family":"Arango-Franco","sequence":"additional","affiliation":[{"name":"Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM) U1163, Necker Hospital for Sick Children, Paris, France."},{"name":"Primary Immunodeficiencies Group, University of Antioquia (UdeA), Medellin, Colombia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3119-662X","authenticated-orcid":true,"given":"Simon","family":"Pelham","sequence":"additional","affiliation":[{"name":"St.\u00a0Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University, New\u00a0York, NY, 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Faculty of Medicine, OMICARE University Hospital Federation, Immunology and Hematology Research Center, Research Center in Biomedicine of Strasbourg (CRBS), Federation of Translational Medicine of Strasbourg (FMTS), University of Strasbourg, Strasbourg, France."},{"name":"Interdisciplinary Thematic Institute (ITI) of Precision Medicine of Strasbourg, Strasbourg, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7036-442X","authenticated-orcid":true,"given":"Raphael","family":"Carapito","sequence":"additional","affiliation":[{"name":"Molecular Immuno-Rheumatology Laboratory, INSERM UMR_S1109, GENOMAX Platform, Faculty of Medicine, OMICARE University Hospital Federation, Immunology and Hematology Research Center, Research Center in Biomedicine of Strasbourg (CRBS), Federation of Translational Medicine of Strasbourg (FMTS), University of Strasbourg, Strasbourg, France."},{"name":"Interdisciplinary Thematic Institute (ITI) of Precision 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