{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T12:05:41Z","timestamp":1791374741956,"version":"4.3.1"},"reference-count":69,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"81","content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Sci. Immunol."],"published-print":{"date-parts":[[2023,3,31]]},"abstract":"<jats:p>\n            IgE-mediated anaphylaxis is an acute life-threatening systemic reaction to allergens, including certain foods and venoms. Anaphylaxis is triggered when blood-borne allergens activate IgE-bound perivascular mast cells (MCs) throughout the body, causing an extensive systemic release of MC mediators. Through precipitating vasodilatation and vascular leakage, these mediators are believed to trigger a sharp drop in blood pressure in humans and in core body temperature in animals. We report that the IgE\/MC-mediated drop in body temperature in mice associated with anaphylaxis also requires the body\u2019s thermoregulatory neural circuit. This circuit is activated when granule-borne chymase from MCs is deposited on proximal TRPV1\n            <jats:sup>+<\/jats:sup>\n            sensory neurons and stimulates them via protease-activated receptor-1. This triggers the activation of the body\u2019s thermoregulatory neural network, which rapidly attenuates brown adipose tissue thermogenesis to cause hypothermia. Mice deficient in either chymase or TRPV1 exhibited limited IgE-mediated anaphylaxis, and, in wild-type mice, anaphylaxis could be recapitulated simply by systemically activating TRPV1\n            <jats:sup>+<\/jats:sup>\n            sensory neurons. Thus, in addition to their well-known effects on the vasculature, MC products, especially chymase, promote IgE-mediated anaphylaxis by activating the thermoregulatory neural circuit.\n          <\/jats:p>","DOI":"10.1126\/sciimmunol.adc9417","type":"journal-article","created":{"date-parts":[[2023,3,17]],"date-time":"2023-03-17T17:58:09Z","timestamp":1679075889000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":68,"title":["A mast cell\u2013thermoregulatory neuron circuit axis regulates hypothermia in anaphylaxis"],"prefix":"10.1126","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5103-2035","authenticated-orcid":true,"given":"Chunjing","family":"Bao","sequence":"first","affiliation":[{"name":"Department of Pathology, Duke University Medical Center, Durham, NC 27710, 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