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These cells shared transcriptional features, including the expression of\n                    <jats:italic>Dpp4<\/jats:italic>\n                    and\n                    <jats:italic>Pi16<\/jats:italic>\n                    , with multipotent progenitor cells (MPC) that have been identified in numerous tissues and are reported to be capable of differentiating into fibroblasts and adipocytes. Concomitantly, mAT became infiltrated with resident T helper 2 (T\n                    <jats:sub>H<\/jats:sub>\n                    2) cells that responded to TSLP and IL-33 by producing stromal cell\u2013stimulating cytokines, including transforming growth factor \u03b21 (TGF\u03b2\n                    <jats:sub>1<\/jats:sub>\n                    ) and amphiregulin. These T\n                    <jats:sub>H<\/jats:sub>\n                    2 cells expressed genes previously associated with type 2 innate lymphoid cells (ILC2), including\n                    <jats:italic>Nmur1<\/jats:italic>\n                    ,\n                    <jats:italic>Calca<\/jats:italic>\n                    ,\n                    <jats:italic>Klrg1<\/jats:italic>\n                    , and\n                    <jats:italic>Arg1<\/jats:italic>\n                    , and persisted in mAT for at least 11 months after anthelmintic drug\u2013mediated clearance of infection. We found that MPC and T\n                    <jats:sub>H<\/jats:sub>\n                    2 cells localized to ECM-rich interstitial spaces that appeared shared between mesenteric lymph node, mAT, and intestine. Stromal cell expression of epidermal growth factor receptor (EGFR), the receptor for amphiregulin, was required for immunity to infection. Our findings point to the importance of MPC and T\n                    <jats:sub>H<\/jats:sub>\n                    2 cell interactions within the interstitium in orchestrating AT remodeling and immunity to an intestinal infection.\n                  <\/jats:p>","DOI":"10.1126\/sciimmunol.add3263","type":"journal-article","created":{"date-parts":[[2022,10,14]],"date-time":"2022-10-14T13:58:23Z","timestamp":1665755903000},"source":"Crossref","is-referenced-by-count":48,"title":["Resident T\n                    <sub>H<\/sub>\n                    2 cells orchestrate adipose tissue remodeling at a site adjacent to infection"],"prefix":"10.1126","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1916-5983","authenticated-orcid":true,"given":"Agnieszka M.","family":"Kabat","sequence":"first","affiliation":[{"name":"Max Planck Institute for Immunobiology and Epigenetics, Freiburg 79108, Germany."},{"name":"Bloomberg Kimmel Institute and Department of Oncology, Johns Hopkins 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