{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T15:48:31Z","timestamp":1789573711618,"version":"build-2803163510"},"reference-count":109,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"86","content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Sci. Immunol."],"published-print":{"date-parts":[[2023,8,4]]},"abstract":"<jats:p>\n            Helminth endemic regions report lower COVID-19 morbidity and mortality. Here, we show that lung remodeling from a prior infection with a lung-migrating helminth,\n            <jats:italic>Nippostrongylus brasiliensis<\/jats:italic>\n            , enhances viral clearance and survival of human-ACE2 transgenic mice challenged with SARS-CoV-2 (SCV2). This protection is associated with a lymphocytic infiltrate, including increased accumulation of pulmonary SCV2-specific CD8\n            <jats:sup>+<\/jats:sup>\n            T cells, and anti-CD8 antibody depletion abrogated the\n            <jats:italic>N. brasiliensis\u2013<\/jats:italic>\n            mediated reduction in viral loads. Pulmonary macrophages with a type 2 transcriptional and epigenetic signature persist in the lungs of\n            <jats:italic>N. brasiliensis<\/jats:italic>\n            \u2013exposed mice after clearance of the parasite and establish a primed environment for increased CD8\n            <jats:sup>+<\/jats:sup>\n            T cell recruitment and activation. Accordingly, depletion of macrophages ablated the augmented viral clearance and accumulation of CD8\n            <jats:sup>+<\/jats:sup>\n            T cells driven by prior\n            <jats:italic>N. brasiliensis<\/jats:italic>\n            infection. Together, these findings support the concept that lung-migrating helminths can limit disease severity during SCV2 infection through macrophage-dependent enhancement of antiviral CD8\n            <jats:sup>+<\/jats:sup>\n            T cell responses.\n          <\/jats:p>","DOI":"10.1126\/sciimmunol.adf8161","type":"journal-article","created":{"date-parts":[[2023,8,11]],"date-time":"2023-08-11T17:58:11Z","timestamp":1691776691000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":27,"title":["Exposure to lung-migrating helminth protects against murine SARS-CoV-2 infection through macrophage-dependent T cell activation"],"prefix":"10.1126","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5347-7502","authenticated-orcid":true,"given":"Oyebola O.","family":"Oyesola","sequence":"first","affiliation":[{"name":"Type 2 Immunity Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious 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