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Concurrent gene expression and DNA accessibility revealed that genes encoding these functional proteins correlated with\n                    <jats:italic>BATF<\/jats:italic>\n                    expression and motif accessibility. IFN-\u03b3\n                    <jats:sup>+<\/jats:sup>\n                    T\n                    <jats:sub>PHEX<\/jats:sub>\n                    effectively killed myeloma with comparable efficacy to transitory effectors, and disease progression correlated with numerical deficits in IFN-\u03b3\n                    <jats:sup>+<\/jats:sup>\n                    T\n                    <jats:sub>PHEX<\/jats:sub>\n                    . We also observed IFN-\u03b3\n                    <jats:sup>+<\/jats:sup>\n                    T\n                    <jats:sub>PHEX<\/jats:sub>\n                    within CD19-targeted chimeric antigen receptor T cells, which killed CD19\n                    <jats:sup>+<\/jats:sup>\n                    leukemia cells. An IFN-\u03b3\n                    <jats:sup>+<\/jats:sup>\n                    T\n                    <jats:sub>PHEX<\/jats:sub>\n                    gene signature was recapitulated in T\n                    <jats:sub>EX<\/jats:sub>\n                    cells from human cancers, including myeloma and lymphoma. Here, we characterize a T\n                    <jats:sub>EX<\/jats:sub>\n                    subset in hematological malignancies that paradoxically retains function and is distinct from dysfunctional T\n                    <jats:sub>EX<\/jats:sub>\n                    found in chronic viral infections. Thus, IFN-\u03b3\n                    <jats:sup>+<\/jats:sup>\n                    T\n                    <jats:sub>PHEX<\/jats:sub>\n                    represent a potential target for immunotherapy of blood cancers.\n                  <\/jats:p>","DOI":"10.1126\/sciimmunol.adg1094","type":"journal-article","created":{"date-parts":[[2024,4,19]],"date-time":"2024-04-19T13:58:10Z","timestamp":1713535090000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":63,"title":["TIM-3\n                    <sup>+<\/sup>\n                    CD8 T cells with a terminally exhausted phenotype retain functional capacity in hematological malignancies"],"prefix":"10.1126","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1314-9264","authenticated-orcid":true,"given":"Simone A.","family":"Minnie","sequence":"first","affiliation":[{"name":"Translational Science and Therapeutics Division, Fred Hutchinson Cancer Center, Seattle, WA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7021-0431","authenticated-orcid":true,"given":"Olivia G.","family":"Waltner","sequence":"additional","affiliation":[{"name":"Translational Science and Therapeutics Division, Fred Hutchinson Cancer Center, Seattle, WA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0311-6725","authenticated-orcid":true,"given":"Ping","family":"Zhang","sequence":"additional","affiliation":[{"name":"Translational Science and Therapeutics Division, Fred Hutchinson Cancer Center, Seattle, WA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3850-0559","authenticated-orcid":true,"given":"Shuichiro","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Translational Science and Therapeutics Division, Fred Hutchinson Cancer Center, Seattle, WA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole S.","family":"Nemychenkov","sequence":"additional","affiliation":[{"name":"Translational Science and Therapeutics Division, Fred Hutchinson Cancer Center, Seattle, WA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen S.","family":"Ensbey","sequence":"additional","affiliation":[{"name":"Translational Science and Therapeutics Division, Fred Hutchinson Cancer Center, Seattle, WA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-2051-0825","authenticated-orcid":true,"given":"Christine R.","family":"Schmidt","sequence":"additional","affiliation":[{"name":"Translational Science and Therapeutics Division, Fred Hutchinson Cancer Center, Seattle, WA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel R. W.","family":"Legg","sequence":"additional","affiliation":[{"name":"Translational Science and Therapeutics Division, Fred Hutchinson Cancer Center, Seattle, WA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-0393-9571","authenticated-orcid":true,"given":"Melissa","family":"Comstock","sequence":"additional","affiliation":[{"name":"Translational Science and Therapeutics Division, Fred Hutchinson Cancer Center, Seattle, WA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-1378-4752","authenticated-orcid":true,"given":"Julie R.","family":"Boiko","sequence":"additional","affiliation":[{"name":"Translational Science and Therapeutics Division, Fred Hutchinson Cancer Center, Seattle, WA, USA."},{"name":"Department of Pediatrics, University of Washington, Seattle, WA, 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