{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T15:50:34Z","timestamp":1791561034993,"version":"4.3.4"},"reference-count":45,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"94","content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Sci. Immunol."],"published-print":{"date-parts":[[2024,4,19]]},"abstract":"<jats:p>\n                    Vedolizumab (VDZ) is a first-line treatment in ulcerative colitis (UC) that targets the \u03b14\u03b27- mucosal vascular addressin cell adhesion molecule 1 (MAdCAM-1) axis. To determine the mechanisms of action of VDZ, we examined five distinct cohorts of patients with UC. A decrease in na\u00efve B and T cells in the intestines and gut-homing (\u03b27\n                    <jats:sup>+<\/jats:sup>\n                    ) plasmablasts in circulation of VDZ-treated patients suggested that VDZ targets gut-associated lymphoid tissue (GALT). Anti-\u03b14\u03b27 blockade in wild-type and photoconvertible (KikGR) mice confirmed a loss of GALT size and cellularity because of impaired cellular entry. In VDZ-treated patients with UC, treatment responders demonstrated reduced intestinal lymphoid aggregate size and follicle organization and a reduction of \u03b27\n                    <jats:sup>+<\/jats:sup>\n                    IgG\n                    <jats:sup>+<\/jats:sup>\n                    plasmablasts in circulation, as well as IgG\n                    <jats:sup>+<\/jats:sup>\n                    plasma cells and Fc\u03b3R-dependent signaling in the intestine. GALT targeting represents a previously unappreciated mechanism of action of \u03b14\u03b27-targeted therapies, with major implications for this therapeutic paradigm in UC.\n                  <\/jats:p>","DOI":"10.1126\/sciimmunol.adg7549","type":"journal-article","created":{"date-parts":[[2024,4,19]],"date-time":"2024-04-19T13:58:10Z","timestamp":1713535090000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":42,"title":["Gut-associated lymphoid tissue attrition associates with response to anti-\u03b14\u03b27 therapy in ulcerative colitis"],"prefix":"10.1126","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1865-6476","authenticated-orcid":true,"given":"Pablo","family":"Canales-Herrerias","sequence":"first","affiliation":[{"name":"Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA."},{"name":"Henry D. 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