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Selective depletion of skin T\n                    <jats:sub>regs<\/jats:sub>\n                    resulted in T cell\u2013mediated inflammation of hair follicles (HFs). Suppression did not rely on CTLA-4, but instead on high-affinity interleukin-2 (IL-2) receptor expression by skin T\n                    <jats:sub>regs<\/jats:sub>\n                    , functioning exclusively in a cell-extrinsic manner. In a novel model of HF stem cell (HFSC)\u2013driven autoimmunity, we reveal that skin T\n                    <jats:sub>regs<\/jats:sub>\n                    immunologically protect the HFSC niche. Finally, we used spatial transcriptomics to identify aberrant IL-2 signaling at stromal-HF interfaces in a rare form of human alopecia characterized by HFSC destruction and alopecia areata. Collectively, these results reveal the fundamental biology of T\n                    <jats:sub>regs<\/jats:sub>\n                    in skin uncoupled from the systemic pool and elucidate a mechanism of self-tolerance.\n                  <\/jats:p>","DOI":"10.1126\/sciimmunol.adh0152","type":"journal-article","created":{"date-parts":[[2024,1,5]],"date-time":"2024-01-05T13:58:26Z","timestamp":1704463106000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":89,"title":["Regulatory T cells in skin mediate immune privilege of the hair follicle stem cell niche"],"prefix":"10.1126","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6043-2177","authenticated-orcid":true,"given":"Jarish N.","family":"Cohen","sequence":"first","affiliation":[{"name":"Department of Dermatology, University of California, San Francisco, San Francisco, CA, USA."},{"name":"Department of Pathology, University of California, San Francisco, San 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T.","family":"Weaver","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Alabama at Birmingham, Birmingham, AL, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9736-2109","authenticated-orcid":true,"given":"Arlene H.","family":"Sharpe","sequence":"additional","affiliation":[{"name":"Department of Immunology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA."},{"name":"Evergrande Center for Immunological Diseases, Harvard Medical School and Brigham and Women\u2019s Hospital, Boston, MA, USA."},{"name":"Department of Pathology, Brigham and Women\u2019s Hospital, Boston, MA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6135-4035","authenticated-orcid":true,"given":"Roberto R.","family":"Ricardo-Gonzalez","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University of California, San Francisco, San Francisco, 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