{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T10:18:46Z","timestamp":1792664326724,"version":"4.5.0"},"reference-count":48,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"103","content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Sci. Immunol."],"published-print":{"date-parts":[[2025,1,10]]},"abstract":"<jats:p>\n            Thymic stromal lymphopoietin (TSLP) is a type I cytokine that promotes allergic responses and mediates type 2 immunity. A balance between effector T cells (T\n            <jats:sub>effs<\/jats:sub>\n            ), which drive the immune response, and regulatory T cells (T\n            <jats:sub>regs<\/jats:sub>\n            ), which suppress the response, is required for proper immune homeostasis. Here, we report that TSLP differentially acts on T\n            <jats:sub>effs<\/jats:sub>\n            versus T\n            <jats:sub>regs<\/jats:sub>\n            to balance type 2 immunity. As expected, deletion of TSLP receptor (TSLPR) on all T cells (\n            <jats:italic>Cd4<\/jats:italic>\n            <jats:sup>Cre<\/jats:sup>\n            <jats:italic>Crlf2<\/jats:italic>\n            <jats:sup>fl\/fl<\/jats:sup>\n            mice) resulted in lower numbers of T helper 2 (T\n            <jats:sub>H<\/jats:sub>\n            2) cells and diminished ovalbumin-induced airway inflammation, but selective deletion of TSLPR on T\n            <jats:sub>regs<\/jats:sub>\n            (\n            <jats:italic>Foxp3<\/jats:italic>\n            <jats:sup>\n              <jats:italic>YFP<\/jats:italic>\n              -Cre\/Y\n            <\/jats:sup>\n            <jats:italic>Crlf2<\/jats:italic>\n            <jats:sup>fl\/fl<\/jats:sup>\n            mice) resulted in increased interleukin-5 (IL-5)\u2013 and IL-13\u2013secreting T\n            <jats:sub>H<\/jats:sub>\n            2 cells and lung eosinophilia. Moreover, TSLP augmented the expression of factors that stabilize T\n            <jats:sub>regs<\/jats:sub>\n            . During type 2 immune responses, TSLPR-deficient T\n            <jats:sub>regs<\/jats:sub>\n            acquired T\n            <jats:sub>H<\/jats:sub>\n            2-like properties, with augmented GATA3 expression and secretion of IL-13. TSLP not only is a driver of T\n            <jats:sub>H<\/jats:sub>\n            2 effector cells but also acts in a negative feedback loop, thus promoting the ability of T\n            <jats:sub>regs<\/jats:sub>\n            to limit allergic inflammation.\n          <\/jats:p>","DOI":"10.1126\/sciimmunol.adk0073","type":"journal-article","created":{"date-parts":[[2025,1,10]],"date-time":"2025-01-10T18:58:32Z","timestamp":1736535512000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":10,"title":["TSLP acts on regulatory T cells to maintain their identity and limit allergic inflammation"],"prefix":"10.1126","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1956-0249","authenticated-orcid":true,"given":"Rama K.","family":"Gurram","sequence":"first","affiliation":[{"name":"Laboratory of Molecular Immunology and Immunology Center, National Heart, Lung, and Blood Institute, National Institutes of Health (NIH), Bethesda, MD 20892, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4721-5936","authenticated-orcid":true,"given":"Peng","family":"Li","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Immunology and Immunology Center, National Heart, Lung, and Blood Institute, National Institutes of Health (NIH), Bethesda, MD 20892, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jangsuk","family":"Oh","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Immunology and Immunology Center, National Heart, Lung, and Blood Institute, National Institutes of Health (NIH), Bethesda, MD 20892, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi","family":"Chen","sequence":"additional","affiliation":[{"name":"Molecular and Cellular Immunoregulation Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-1511-9349","authenticated-orcid":true,"given":"Rosanne","family":"Spolski","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Immunology and Immunology Center, National Heart, Lung, and Blood Institute, National Institutes of Health (NIH), Bethesda, MD 20892, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianglan","family":"Yao","sequence":"additional","affiliation":[{"name":"Critical Care Medicine and Pulmonary Branch, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD 20892-1674, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5849-9412","authenticated-orcid":true,"given":"Jian-Xin","family":"Lin","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Immunology and Immunology Center, National Heart, Lung, and Blood Institute, National Institutes of Health (NIH), Bethesda, MD 20892, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0332-4962","authenticated-orcid":true,"given":"Suyasha","family":"Roy","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Immunology and Immunology Center, National Heart, Lung, and Blood Institute, National Institutes of Health (NIH), Bethesda, MD 20892, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8130-9848","authenticated-orcid":true,"given":"Matthew J.","family":"Liao","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Immunology and Immunology Center, National Heart, Lung, and Blood Institute, National Institutes of Health (NIH), Bethesda, MD 20892, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5136-9225","authenticated-orcid":true,"given":"Chengyu","family":"Liu","sequence":"additional","affiliation":[{"name":"Transgenic Core, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD 20892, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1341-4486","authenticated-orcid":true,"given":"Zu-Xi","family":"Yu","sequence":"additional","affiliation":[{"name":"Pathology Core, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD 20892, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9313-9746","authenticated-orcid":true,"given":"Stewart J.","family":"Levine","sequence":"additional","affiliation":[{"name":"Critical Care Medicine and Pulmonary Branch, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD 20892-1674, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0117-4745","authenticated-orcid":true,"given":"Jinfang","family":"Zhu","sequence":"additional","affiliation":[{"name":"Molecular and Cellular Immunoregulation Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5740-7448","authenticated-orcid":true,"given":"Warren J.","family":"Leonard","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Immunology and Immunology Center, National Heart, Lung, and Blood Institute, National Institutes of Health (NIH), Bethesda, MD 20892, 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