{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T15:25:33Z","timestamp":1793201133307,"version":"4.5.0"},"reference-count":98,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"109","content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Sci. Immunol."],"published-print":{"date-parts":[[2025,7,18]]},"abstract":"<jats:p>\n            Ulcerative colitis (UC) develops through a complicated interaction between the host and microbiota. Intestinal fibroblasts are believed to play crucial roles in the pathogenesis of UC, but the influence of the host-microbiota interaction on the pathophysiology of intestinal fibroblasts remains poorly understood. Here, we demonstrate that OTU deubiquitinase 3 (OTUD3) suppresses pathologic activation of fibroblasts exposed to microbial cyclic GMP-AMP (3\u20323\u2019-cGAMP) in the colon by deubiquitinating stimulator of interferon genes (STING). Mice harboring a UC risk missense variant in the\n            <jats:italic>Otud3<\/jats:italic>\n            gene showed pathological features of UC in the colon after transplantation of a fecal microbiota with the potential to produce excessive cGAMP from patients with UC. Collectively, these results highlight a mechanism of the interaction between OTUD3 in host fibroblasts and STING-activating microbiota in UC development.\n          <\/jats:p>","DOI":"10.1126\/sciimmunol.adm6843","type":"journal-article","created":{"date-parts":[[2025,7,18]],"date-time":"2025-07-18T17:58:50Z","timestamp":1752861530000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":17,"title":["OTUD3 prevents ulcerative colitis by inhibiting microbiota-mediated STING activation"],"prefix":"10.1126","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6595-7485","authenticated-orcid":true,"given":"Bo","family":"Li","sequence":"first","affiliation":[{"name":"Laboratory of Immune Regulation, Department of Microbiology and Immunology, Graduate School of Medicine, University of Osaka, Suita, Osaka 565-0871, Japan."},{"name":"Department of Gastroenterology, Endoscopy Center, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai 200136, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2661-0646","authenticated-orcid":true,"given":"Taiki","family":"Sakaguchi","sequence":"additional","affiliation":[{"name":"Laboratory of Immune Regulation, Department of Microbiology and Immunology, Graduate School of Medicine, University of Osaka, Suita, Osaka 565-0871, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haruka","family":"Tani","sequence":"additional","affiliation":[{"name":"Laboratory of Immune Regulation, Department of Microbiology and Immunology, Graduate School of Medicine, University of Osaka, Suita, Osaka 565-0871, Japan."},{"name":"WPI Immunology Frontier Research Center, University of Osaka, Suita, Osaka 565-0871, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-8915-2560","authenticated-orcid":true,"given":"Takayoshi","family":"Ito","sequence":"additional","affiliation":[{"name":"Laboratory of Immune Regulation, Department of Microbiology and Immunology, Graduate School of Medicine, University of Osaka, Suita, Osaka 565-0871, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6458-8235","authenticated-orcid":true,"given":"Mari","family":"Murakami","sequence":"additional","affiliation":[{"name":"Laboratory of Immune Regulation, Department of Microbiology and Immunology, Graduate School of Medicine, University of Osaka, Suita, Osaka 565-0871, Japan."},{"name":"WPI Immunology Frontier Research Center, University of Osaka, Suita, Osaka 565-0871, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9569-4591","authenticated-orcid":true,"given":"Ryu","family":"Okumura","sequence":"additional","affiliation":[{"name":"Laboratory of Immune Regulation, Department of Microbiology and Immunology, Graduate School of Medicine, University of Osaka, Suita, Osaka 565-0871, Japan."},{"name":"WPI Immunology Frontier Research Center, University of Osaka, Suita, Osaka 565-0871, Japan."},{"name":"Integrated Frontier Research for Medical Science Division, Institute for Open and Transdisciplinary Research Initiatives, University of Osaka, Suita, Osaka 565-0871, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-8442-7879","authenticated-orcid":true,"given":"Masao","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Laboratory of Immune Regulation, Department of Microbiology and Immunology, Graduate School of Medicine, University of Osaka, Suita, Osaka 565-0871, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4552-783X","authenticated-orcid":true,"given":"Daisuke","family":"Okuzaki","sequence":"additional","affiliation":[{"name":"WPI Immunology Frontier Research Center, University of Osaka, Suita, Osaka 565-0871, Japan."},{"name":"Integrated Frontier Research for Medical Science Division, Institute for Open and Transdisciplinary Research Initiatives, University of Osaka, Suita, Osaka 565-0871, Japan."},{"name":"Genome Information Research Center, Research Institute for Microbial Diseases, University of Osaka, Suita, Osaka 565-0871, Japan."},{"name":"Center for Infectious Disease Education and Research, University of Osaka, Suita, Osaka 565-0871, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4616-9608","authenticated-orcid":true,"given":"Daisuke","family":"Motooka","sequence":"additional","affiliation":[{"name":"WPI Immunology Frontier Research Center, University of Osaka, Suita, Osaka 565-0871, Japan."},{"name":"Integrated Frontier Research for Medical Science Division, Institute for Open and Transdisciplinary Research Initiatives, University of Osaka, Suita, Osaka 565-0871, Japan."},{"name":"Genome Information Research Center, Research Institute for Microbial Diseases, University of Osaka, Suita, Osaka 565-0871, Japan."},{"name":"Department of Infection Metagenomics, Research Institute for Microbial Diseases, University of Osaka, Suita, Osaka 565-0871, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9144-5782","authenticated-orcid":true,"given":"Hiroki","family":"Ikeuchi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological Surgery, Division of Inflammatory Bowel Disease Surgery, Hyogo Medical University, Nishinomiya, Hyogo 663-8501, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5435-4144","authenticated-orcid":true,"given":"Takayuki","family":"Ogino","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological Surgery, Graduate School of Medicine, University of Osaka, Suita, Osaka 565-0871, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0825-6823","authenticated-orcid":true,"given":"Tsunekazu","family":"Mizushima","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological Surgery, Graduate School of Medicine, University of Osaka, Suita, Osaka 565-0871, Japan."},{"name":"Department of Gastroenterological Surgery, Osaka Police Hospital, Osaka, Osaka 543-0035, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seiichi","family":"Hirota","sequence":"additional","affiliation":[{"name":"Department of Surgical Pathology, Hyogo Medical University, Nishinomiya, Hyogo 663-8501, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8822-9544","authenticated-orcid":true,"given":"Yuriko","family":"Otake-Kasamoto","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Graduate School of Medicine, University of Osaka, Suita, Osaka 565-0871, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0590-3965","authenticated-orcid":true,"given":"Toshihiro","family":"Kishikawa","sequence":"additional","affiliation":[{"name":"Department of Statistical Genetics, Graduate School of Medicine, University of Osaka, Suita, Osaka 565-0871, Japan."},{"name":"Department of Head and Neck Surgery, Aichi Cancer Center Hospital, Nagoya, Aichi 464-8681, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2058-5942","authenticated-orcid":true,"given":"Shota","family":"Nakamura","sequence":"additional","affiliation":[{"name":"WPI Immunology Frontier Research Center, University of Osaka, Suita, Osaka 565-0871, Japan."},{"name":"Integrated Frontier Research for Medical Science Division, Institute for Open and Transdisciplinary Research Initiatives, University of Osaka, Suita, Osaka 565-0871, Japan."},{"name":"Genome Information Research Center, Research Institute for Microbial Diseases, University of Osaka, Suita, Osaka 565-0871, Japan."},{"name":"Department of Infection Metagenomics, Research Institute for Microbial Diseases, University of Osaka, Suita, Osaka 565-0871, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5846-4807","authenticated-orcid":true,"given":"Kouji","family":"Kobiyama","sequence":"additional","affiliation":[{"name":"Division of Vaccine Science, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo (IMSUT), Tokyo 108-8639, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6728-3872","authenticated-orcid":true,"given":"Ken J.","family":"Ishii","sequence":"additional","affiliation":[{"name":"WPI Immunology Frontier Research Center, University of Osaka, Suita, Osaka 565-0871, Japan."},{"name":"Division of Vaccine Science, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo (IMSUT), Tokyo 108-8639, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7578-7571","authenticated-orcid":true,"given":"Takao","family":"Hashiguchi","sequence":"additional","affiliation":[{"name":"Institute for Life and Medical Sciences, Kyoto University, Kyoto, Kyoto 606-8507, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7510-4662","authenticated-orcid":true,"given":"Taro","family":"Kawai","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Immunobiology, Division of Biological Science, Graduate School of Science and Technology, Nara Institute of Science and Technology (NAIST), Ikoma, Nara 630-0192, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7198-2190","authenticated-orcid":true,"given":"Etsushi","family":"Kuroda","sequence":"additional","affiliation":[{"name":"Department of Immunology, School of Medicine, Hyogo Medical University, Nishinomiya, Hyogo 663-8501, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7051-618X","authenticated-orcid":true,"given":"Shinichiro","family":"Shinzaki","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Graduate School of Medicine, University of Osaka, Suita, Osaka 565-0871, Japan."},{"name":"Department of Gastroenterology, Hyogo Medical University, Nishinomiya, Hyogo 663-8501, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0457-3386","authenticated-orcid":true,"given":"Wataru","family":"Ise","sequence":"additional","affiliation":[{"name":"WPI Immunology Frontier Research Center, University of Osaka, Suita, Osaka 565-0871, Japan."},{"name":"Center for Infectious Disease Education and Research, University of Osaka, Suita, Osaka 565-0871, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6352-304X","authenticated-orcid":true,"given":"Tomohiro","family":"Kurosaki","sequence":"additional","affiliation":[{"name":"WPI Immunology Frontier Research Center, University of Osaka, Suita, Osaka 565-0871, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3378-9522","authenticated-orcid":true,"given":"Akira","family":"Kikuchi","sequence":"additional","affiliation":[{"name":"Center for Infectious Disease Education and Research, University of Osaka, Suita, Osaka 565-0871, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1661-0941","authenticated-orcid":true,"given":"Yoshihiko","family":"Tomofuji","sequence":"additional","affiliation":[{"name":"Department of Statistical Genetics, Graduate School of Medicine, University of Osaka, Suita, Osaka 565-0871, Japan."},{"name":"Department of Genome Informatics, Graduate School of Medicine, University of Tokyo, Tokyo 113-0033, Japan."},{"name":"Laboratory for Systems Genetics, RIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa 230-0045, Japan."},{"name":"Center for Data Sciences, Brigham and Women\u2019s Hospital, Boston, MA 02115, USA."},{"name":"Divisions of Genetics and Rheumatology, Department of Medicine, Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, MA 02115, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0311-8472","authenticated-orcid":true,"given":"Yukinori","family":"Okada","sequence":"additional","affiliation":[{"name":"WPI Immunology Frontier Research Center, University of Osaka, Suita, Osaka 565-0871, Japan."},{"name":"Genome Information Research Center, Research Institute for Microbial Diseases, University of Osaka, Suita, Osaka 565-0871, Japan."},{"name":"Department of Statistical Genetics, Graduate School of Medicine, University of Osaka, Suita, Osaka 565-0871, Japan."},{"name":"Department of Genome Informatics, Graduate School of Medicine, University of Tokyo, Tokyo 113-0033, Japan."},{"name":"Laboratory for Systems Genetics, RIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa 230-0045, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1778-6332","authenticated-orcid":true,"given":"Kiyoshi","family":"Takeda","sequence":"additional","affiliation":[{"name":"Laboratory of Immune Regulation, Department of Microbiology and Immunology, Graduate School of Medicine, University of Osaka, Suita, Osaka 565-0871, Japan."},{"name":"WPI Immunology Frontier Research Center, University of Osaka, Suita, Osaka 565-0871, Japan."},{"name":"Integrated Frontier Research for Medical Science Division, Institute for Open and Transdisciplinary Research Initiatives, University of Osaka, Suita, Osaka 565-0871, Japan."},{"name":"Center for Infectious Disease Education and Research, University of Osaka, Suita, Osaka 565-0871, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5676-8228","authenticated-orcid":true,"given":"Hisako","family":"Kayama","sequence":"additional","affiliation":[{"name":"Laboratory of Immune Regulation, Department of Microbiology and Immunology, Graduate School of Medicine, University of Osaka, Suita, Osaka 565-0871, Japan."},{"name":"WPI Immunology Frontier Research Center, University of Osaka, Suita, Osaka 565-0871, Japan."},{"name":"Institute for Advanced Co-Creation Studies, University of Osaka, Suita, Osaka 565-0871, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2019-318484"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(19)30333-4"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2017.88"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2015.34"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2018.08.067"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2019.08.008"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-021-01520-5"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-03484-5"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature11582"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3760"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(93)80068-P"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.66.11.5224-5231.1998"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.1999.276.6.G1461"},{"key":"e_1_3_2_15_2","first-page":"91","article-title":"T cell receptor-alpha beta-deficient mice fail to develop colitis in the absence of a microbial environment","volume":"150","author":"Dianda L.","year":"1997","unstructured":"L. Dianda, A. M. Hanby, N. A. Wright, A. Sebesteny, A. C. Hayday, M. J. Owen, T cell receptor-alpha beta-deficient mice fail to develop colitis in the absence of a microbial environment. Am. J. Pathol. 150, 91\u201397 (1997).","journal-title":"Am. J. Pathol."},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2022.01.006"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng.549"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3359"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng.275"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-019-0550-4"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2020.06.020"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2022.110920"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2022.05.005"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.18632\/aging.203293"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncb3218"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-10824-7"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-27348-8"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-021-00524-z"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2021.05.008"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2017.11.101"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-50656-5"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2023.112309"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-020-0198-7"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1402051"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2017.88"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-09234-6"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2020.03.016"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1553-0"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2020.01.014"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-024-07571-1"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1605-5"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2719-5"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41564-020-0777-y"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-0953-5"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2020.05.013"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1229963"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20211291"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2019.04.002"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41564-018-0306-4"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1237-9"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41564-021-01050-3"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.anaerobe.2019.102113"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-019-1879-9"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-022-01905-4"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.01500-13"},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2003.09.020"},{"key":"e_1_3_2_57_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-019-05969-w"},{"key":"e_1_3_2_58_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-018-5234-x"},{"key":"e_1_3_2_59_2","doi-asserted-by":"publisher","DOI":"10.1186\/1755-1536-6-13"},{"key":"e_1_3_2_60_2","doi-asserted-by":"publisher","DOI":"10.1097\/MIB.0b013e3182802ab6"},{"key":"e_1_3_2_61_2","doi-asserted-by":"publisher","DOI":"10.1038\/nsmb.2780"},{"key":"e_1_3_2_62_2","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.6b04031"},{"key":"e_1_3_2_63_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.str.2016.01.007"},{"key":"e_1_3_2_64_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-021-00543-0"},{"key":"e_1_3_2_65_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-020-0205-x"},{"key":"e_1_3_2_66_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2002.01264.x"},{"key":"e_1_3_2_67_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-963378"},{"key":"e_1_3_2_68_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.revmed.2008.11.008"},{"key":"e_1_3_2_69_2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v13.i26.3638"},{"key":"e_1_3_2_70_2","first-page":"438","article-title":"Acute ulcerative colitis during successful interferon\/ribavirin treatment for chronic hepatitis","volume":"54","author":"Sprenger R.","year":"2005","unstructured":"R. Sprenger, M. Sagmeister, F. Offner, Acute ulcerative colitis during successful interferon\/ribavirin treatment for chronic hepatitis. Gut 54, 438\u2013439 (2005).","journal-title":"Gut"},{"key":"e_1_3_2_71_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2006.105197"},{"key":"e_1_3_2_72_2","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2023-329628"},{"key":"e_1_3_2_73_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-018-1439-1"},{"key":"e_1_3_2_74_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-012-0673-1"},{"key":"e_1_3_2_75_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1008942828960"},{"key":"e_1_3_2_76_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.02212"},{"key":"e_1_3_2_77_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2100594118"},{"key":"e_1_3_2_78_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22042028"},{"key":"e_1_3_2_79_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1827.2011.02647.x"},{"key":"e_1_3_2_80_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep10536"},{"key":"e_1_3_2_81_2","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjy035"},{"key":"e_1_3_2_82_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00216-021-03628-6"},{"key":"e_1_3_2_83_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41385-019-0219-4"},{"key":"e_1_3_2_84_2","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/dxad050"},{"key":"e_1_3_2_85_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btu170"},{"key":"e_1_3_2_86_2","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.1923"},{"key":"e_1_3_2_87_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btr026"},{"key":"e_1_3_2_88_2","doi-asserted-by":"publisher","DOI":"10.1093\/dnares\/dsw002"},{"key":"e_1_3_2_89_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-0965-1"},{"key":"e_1_3_2_90_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41587-018-0009-7"},{"key":"e_1_3_2_91_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41587-018-0008-8"},{"key":"e_1_3_2_92_2","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2019-215743"},{"key":"e_1_3_2_93_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btv033"},{"key":"e_1_3_2_94_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkq275"},{"key":"e_1_3_2_95_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/28.1.27"},{"key":"e_1_3_2_96_2","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.3176"},{"key":"e_1_3_2_97_2","doi-asserted-by":"publisher","DOI":"10.1038\/jhg.2016.72"},{"key":"e_1_3_2_98_2","doi-asserted-by":"publisher","DOI":"10.1093\/biomet\/69.3.635"},{"key":"e_1_3_2_99_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.xgen.2022.100219"}],"container-title":["Science Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/sciimmunol.adm6843","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,18]],"date-time":"2025-07-18T17:58:54Z","timestamp":1752861534000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/sciimmunol.adm6843"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,18]]},"references-count":98,"journal-issue":{"issue":"109","published-print":{"date-parts":[[2025,7,18]]}},"alternative-id":["10.1126\/sciimmunol.adm6843"],"URL":"https:\/\/doi.org\/10.1126\/sciimmunol.adm6843","relation":{},"ISSN":["2470-9468"],"issn-type":[{"value":"2470-9468","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,18]]},"assertion":[{"value":"2023-10-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-19","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-04","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-18","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"eadm6843"}}