{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T01:47:56Z","timestamp":1791942476100,"version":"4.3.4"},"reference-count":117,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"97","content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Sci. Immunol."],"published-print":{"date-parts":[[2024,7,12]]},"abstract":"<jats:p>\n                    Infections and neurodegenerative diseases induce neuroinflammation, but affected individuals often show nonneural symptoms including muscle pain and muscle fatigue. The molecular pathways by which neuroinflammation causes pathologies outside the central nervous system (CNS) are poorly understood. We developed multiple models to investigate the impact of CNS stressors on motor function and found that\n                    <jats:italic>Escherichia coli<\/jats:italic>\n                    infections and SARS-CoV-2 protein expression caused reactive oxygen species (ROS) to accumulate in the brain. ROS induced expression of the cytokine Unpaired 3 (Upd3) in\n                    <jats:italic>Drosophila<\/jats:italic>\n                    and its ortholog, IL-6, in mice. CNS-derived Upd3\/IL-6 activated the JAK-STAT pathway in skeletal muscle, which caused muscle mitochondrial dysfunction and impaired motor function. We observed similar phenotypes after expressing toxic amyloid-\u03b2 (A\u03b242) in the CNS. Infection and chronic disease therefore activate a systemic brain-muscle signaling axis in which CNS-derived cytokines bypass the connectome and directly regulate muscle physiology, highlighting IL-6 as a therapeutic target to treat disease-associated muscle dysfunction.\n                  <\/jats:p>","DOI":"10.1126\/sciimmunol.adm7908","type":"journal-article","created":{"date-parts":[[2024,7,12]],"date-time":"2024-07-12T13:58:14Z","timestamp":1720792694000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":42,"title":["Infection and chronic disease activate a systemic brain-muscle signaling axis"],"prefix":"10.1126","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7929-0244","authenticated-orcid":true,"given":"Shuo","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Developmental Biology, Washington University School of Medicine in St. Louis, St. Louis, MO 63110, USA."},{"name":"Department of Genetics and Genetics Engineering, School of Life Science, Fudan University, Shanghai 200438, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0547-9447","authenticated-orcid":true,"given":"Meijie","family":"Tian","sequence":"additional","affiliation":[{"name":"Genetics Branch, Oncogenomics Section, National Cancer Institute, NIH, Bethesda, MD 20892, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yulong","family":"Dai","sequence":"additional","affiliation":[{"name":"New Cornerstone Science Laboratory, Tsinghua University-Peking University Joint Center for Life Sciences, School of Basic Medical Sciences, Tsinghua University, Beijing 100084, China."},{"name":"Institute of Infectious Diseases, Shenzhen Bay Laboratory, Shenzhen 518000, China."},{"name":"State Key Laboratory for Animal Disease Control and Prevention, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin 150069, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Genetics and Genetics Engineering, School of Life Science, Fudan University, Shanghai 200438, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-5665-422X","authenticated-orcid":true,"given":"Shigehiro","family":"Yamada","sequence":"additional","affiliation":[{"name":"Department of Developmental Biology, Washington University School of Medicine in St. Louis, St. Louis, MO 63110, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengyong","family":"Feng","sequence":"additional","affiliation":[{"name":"New Cornerstone Science Laboratory, Tsinghua University-Peking University Joint Center for Life Sciences, School of Basic Medical Sciences, Tsinghua University, Beijing 100084, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2517-1661","authenticated-orcid":true,"given":"Yunyun","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Forensic Medicine, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, Hubei 430074, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3971-7589","authenticated-orcid":true,"given":"Deepak","family":"Chhangani","sequence":"additional","affiliation":[{"name":"Department of Neurology and McKnight Brain Institute, Department of Neuroscience and Center for Translational Research in Neurodegenerative Disease, Genetics Institute, and Norman Fixel Institute for Neurological Diseases, University of Florida College of Medicine, Gainesville, FL 32611, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiffany","family":"Ou","sequence":"additional","affiliation":[{"name":"Department of Developmental Biology, Washington University School of Medicine in St. Louis, St. Louis, MO 63110, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2933-646X","authenticated-orcid":true,"given":"Wenle","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics &amp; Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen 361102, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5259-7345","authenticated-orcid":true,"given":"Xuan","family":"Guo","sequence":"additional","affiliation":[{"name":"Life Science Institute, Jinzhou Medical University, Jinzhou 121001, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0898-4879","authenticated-orcid":true,"given":"Jennifer","family":"McAdow","sequence":"additional","affiliation":[{"name":"Department of Developmental Biology, Washington University School of Medicine in St. Louis, St. Louis, MO 63110, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3099-0642","authenticated-orcid":true,"given":"Diego E.","family":"Rincon-Limas","sequence":"additional","affiliation":[{"name":"Department of Neurology and McKnight Brain Institute, Department of Neuroscience and Center for Translational Research in Neurodegenerative Disease, Genetics Institute, and Norman Fixel Institute for Neurological Diseases, University of Florida College of Medicine, Gainesville, FL 32611, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2357-6718","authenticated-orcid":true,"given":"Xin","family":"Yin","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Animal Disease Control and Prevention, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin 150069, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9864-8993","authenticated-orcid":true,"given":"Wanbo","family":"Tai","sequence":"additional","affiliation":[{"name":"Institute of Infectious Diseases, Shenzhen Bay Laboratory, Shenzhen 518000, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7447-5488","authenticated-orcid":true,"given":"Gong","family":"Cheng","sequence":"additional","affiliation":[{"name":"New Cornerstone Science Laboratory, Tsinghua University-Peking University Joint Center for Life Sciences, School of Basic Medical Sciences, Tsinghua University, Beijing 100084, China."},{"name":"Institute of Infectious Diseases, Shenzhen Bay Laboratory, Shenzhen 518000, China."},{"name":"Institute of Pathogenic Organisms, Shenzhen Center for Disease Control and Prevention, Shenzhen 518055, China."},{"name":"Southwest United Graduate School, Kunming 650092, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2783-5636","authenticated-orcid":true,"given":"Aaron","family":"Johnson","sequence":"additional","affiliation":[{"name":"Department of Developmental Biology, Washington University School of Medicine in St. Louis, St. Louis, MO 63110, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2021.680858"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciw878"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.abq3059"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41582-020-00435-y"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41582-019-0244-7"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2010.02.016"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aag2590"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1306220110"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40478-021-01264-w"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.abn0910"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-03756-0"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2019.07.001"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1409427111"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.329110.119"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2022.01.005"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.2337\/diab.10.3.232"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrd.2016.153"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-22599-x"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3691"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2019.00500"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.071464"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e15-07-0546"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-9822(01)00524-3"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2022.111143"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-2896.2004.0133.x"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202000965RR"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2021.109553"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.12867"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.archger.2020.104131"},{"key":"e_1_3_2_31_2","first-page":"57","article-title":"Circulating interleukin-6 is associated with skeletal muscle strength, quality, and functional adaptation with exercise training in mobility-limited older adults","volume":"9","author":"Grosicki G. J.","year":"2020","unstructured":"G. J. Grosicki, B. B. Barrett, D. A. Englund, C. Liu, T. G. Travison, T. Cederholm, A. Koochek, A. Von Berens, T. Gustafsson, T. Benard, K. F. Reid, R. A. Fielding, Circulating interleukin-6 is associated with skeletal muscle strength, quality, and functional adaptation with exercise training in mobility-limited older adults. J. Frailty Aging 9, 57\u201363 (2020).","journal-title":"J. Frailty Aging"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1113\/JP281220"},{"key":"e_1_3_2_33_2","article-title":"Exercise mimetics and JAK inhibition attenuate IFN-\u03b3\u2013induced wasting in engineered human skeletal muscle","volume":"7","author":"Chen Z.","year":"2021","unstructured":"Z. Chen, B. Li, R. Z. Zhan, L. Rao, N. Bursac, Exercise mimetics and JAK inhibition attenuate IFN-\u03b3\u2013induced wasting in engineered human skeletal muscle. Sci. Adv. 7, eabd9502 (2021).","journal-title":"Sci. Adv."},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.956795"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2021.03.005"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2011.11.016"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature07151"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00254-18"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2018.05.022"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1534\/genetics.111.132290"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1242\/dmm.040816"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2009.04.019"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.118.2.401"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1534\/genetics.119.302964"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkaa1026"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-022-02001-z"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-022-01909-w"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.revmed.2019.10.339"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-15578-9"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.17206"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(94)90022-1"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abj4991"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1005595"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2015.03.012"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1827009"},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2020.108368"},{"key":"e_1_3_2_57_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-12336-w"},{"key":"e_1_3_2_58_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2008.07.024"},{"key":"e_1_3_2_59_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1007091"},{"key":"e_1_3_2_60_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0806291105"},{"key":"e_1_3_2_61_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncb1713"},{"key":"e_1_3_2_62_2","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.51595"},{"key":"e_1_3_2_63_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-03710-0"},{"key":"e_1_3_2_64_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2200960119"},{"key":"e_1_3_2_65_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20202135"},{"key":"e_1_3_2_66_2","first-page":"85456","article-title":"Understanding the role of SARS-CoV-2 ORF3a in viral pathogenesis and COVID-19","volume":"13","author":"Zhang J.","year":"2022","unstructured":"J. Zhang, A. Ejikemeuwa, V. Gerzanich, M. Nasr, Q. Tang, J. M. Simard, R. Y. Zhao, Understanding the role of SARS-CoV-2 ORF3a in viral pathogenesis and COVID-19, Front. Microbiol. 13, 854567 (2022).","journal-title":"Front. Microbiol."},{"key":"e_1_3_2_67_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciac722"},{"key":"e_1_3_2_68_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-023-01601-2"},{"key":"e_1_3_2_69_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)32656-8"},{"key":"e_1_3_2_70_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2215-0366(21)00084-5"},{"key":"e_1_3_2_71_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-30836-0"},{"key":"e_1_3_2_72_2","first-page":"2157","article-title":"Assaying locomotor activity to study circadian rhythms and sleep parameters in Drosophila","volume":"43","author":"Chiu J. C.","year":"2010","unstructured":"J. C. Chiu, K. H. Low, D. H. Pike, E. Yildirim, I. Edery, Assaying locomotor activity to study circadian rhythms and sleep parameters in Drosophila. J. Vis. Exp. 43, 2157 (2010). 10.3791\/2157.","journal-title":"J. Vis. Exp."},{"key":"e_1_3_2_73_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5629-08.2009"},{"key":"e_1_3_2_74_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.25.022106.141615"},{"key":"e_1_3_2_75_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M113.543884"},{"key":"e_1_3_2_76_2","doi-asserted-by":"publisher","DOI":"10.1038\/s43587-022-00214-y"},{"key":"e_1_3_2_77_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-021-00726-w"},{"key":"e_1_3_2_78_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro2820"},{"key":"e_1_3_2_79_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-12632-5"},{"key":"e_1_3_2_80_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41594-021-00619-0"},{"key":"e_1_3_2_81_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2021.10.006"},{"key":"e_1_3_2_82_2","doi-asserted-by":"publisher","DOI":"10.1210\/endrev\/bnaa016"},{"key":"e_1_3_2_83_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-25015-6"},{"key":"e_1_3_2_84_2","doi-asserted-by":"crossref","unstructured":"S. J. Flint V. R. Racaniello G. F. Rall A. M. Skalka L. W. Enquist Principles of Virology (ASM Press ed. 4 2015).","DOI":"10.1128\/9781555819521"},{"key":"e_1_3_2_85_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2020.04.013"},{"key":"e_1_3_2_86_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2017-316201"},{"key":"e_1_3_2_87_2","doi-asserted-by":"publisher","DOI":"10.1007\/s43657-022-00077-8"},{"key":"e_1_3_2_88_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddr100"},{"key":"e_1_3_2_89_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2021.08.010"},{"key":"e_1_3_2_90_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0101815"},{"key":"e_1_3_2_91_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.90.21.10061"},{"key":"e_1_3_2_92_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(09)70306-8"},{"key":"e_1_3_2_93_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro1952"},{"key":"e_1_3_2_94_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2014.05.003"},{"key":"e_1_3_2_95_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2022.06.008"},{"key":"e_1_3_2_96_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-022-04569-5"},{"key":"e_1_3_2_97_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(22)01214-4"},{"key":"e_1_3_2_98_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41579-022-00846-2"},{"key":"e_1_3_2_99_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1462-5822.2006.00688.x"},{"key":"e_1_3_2_100_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni1237"},{"key":"e_1_3_2_101_2","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202300149R"},{"key":"e_1_3_2_102_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2023.112842"},{"key":"e_1_3_2_103_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10787-021-00889-6"},{"key":"e_1_3_2_104_2","doi-asserted-by":"publisher","DOI":"10.1093\/function\/zqab045"},{"key":"e_1_3_2_105_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2022.111573"},{"key":"e_1_3_2_106_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41589-024-01571-y"},{"key":"e_1_3_2_107_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(21)00081-3"},{"key":"e_1_3_2_108_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2023.1135145"},{"key":"e_1_3_2_109_2","unstructured":"M. Haq G. Adnan Ruxolitinib in StatPearls [Internet] (StatPearls Publishing 2022); www.ncbi.nlm.nih.gov\/books\/NBK570600\/."},{"key":"e_1_3_2_110_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-03-643544"},{"key":"e_1_3_2_111_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-020-04243-8"},{"key":"e_1_3_2_112_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-62703-679-5_11"},{"key":"e_1_3_2_113_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20170600"},{"key":"e_1_3_2_114_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.xpro.2022.101322"},{"key":"e_1_3_2_115_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2011.09.013"},{"key":"e_1_3_2_116_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkae013"},{"key":"e_1_3_2_117_2","doi-asserted-by":"publisher","DOI":"10.1101\/pdb.prot086280"},{"key":"e_1_3_2_118_2","doi-asserted-by":"publisher","DOI":"10.1038\/tp.2012.120"}],"container-title":["Science Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/sciimmunol.adm7908","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,12]],"date-time":"2024-07-12T13:58:29Z","timestamp":1720792709000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/sciimmunol.adm7908"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,12]]},"references-count":117,"journal-issue":{"issue":"97","published-print":{"date-parts":[[2024,7,12]]}},"alternative-id":["10.1126\/sciimmunol.adm7908"],"URL":"https:\/\/doi.org\/10.1126\/sciimmunol.adm7908","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2020.12.20.423533","asserted-by":"object"}]},"ISSN":["2470-9468"],"issn-type":[{"value":"2470-9468","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,12]]},"assertion":[{"value":"2023-11-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-04-18","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-06-18","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-12","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"eadm7908"}}