{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T06:10:37Z","timestamp":1791612637614,"version":"4.3.4"},"reference-count":43,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"107","content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Sci. Immunol."],"published-print":{"date-parts":[[2025,5,9]]},"abstract":"<jats:p>\n                    Neutralizing anti\u2013interferon-\u03b3 (IFN-\u03b3) autoantibodies (nAIGAs) impair IFN-\u03b3\u2013mediated immunity, predisposing patients with nAIGAs to infection by nontuberculous mycobacteria,\n                    <jats:italic toggle=\"yes\">Talaromyces marneffei<\/jats:italic>\n                    , and other intracellular pathogens. Current clinical management relies on continuous antimicrobial therapy, with no treatment offering sustained benefits. Here, we developed human chimeric autoantibody receptor (CAAR) T cells targeting autoreactive B cells expressing nAIGA B cell receptors (BCRs) using an IFN-\u03b3 receptor\u2013irresponsive IFN-\u03b3 variant as bait. By exploiting a mouse model of nAIGA BCR-expressing B cell leukemia, we found that IFN-\u03b3 CAAR T cells lack off-target toxicity, including IFN-\u03b3 receptor cross-reactive toxicity and Fc-redirected toxicity. IFN-\u03b3 CAAR T cells substantially reduced circulating AIGAs secreted from target cells in vivo. Further, IFN-\u03b3 CAAR T cells effectively eliminated autoreactive B cells in ex vivo cultures of peripheral blood mononuclear cells from patients with nAIGAs. Together, these results demonstrate that IFN-\u03b3 CAAR T cells may be a promising strategy to ameliorate nAIGA-associated infections by eliminating autoreactive B cells.\n                  <\/jats:p>","DOI":"10.1126\/sciimmunol.adm8186","type":"journal-article","created":{"date-parts":[[2025,5,9]],"date-time":"2025-05-09T13:58:16Z","timestamp":1746799096000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":22,"title":["Chimeric autoantibody receptor T cells clonally eliminate B cells producing autoantibodies against IFN-\u03b3"],"prefix":"10.1126","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8923-9234","authenticated-orcid":true,"given":"Jhan-Jie","family":"Peng","sequence":"first","affiliation":[{"name":"Center for Molecular and Clinical Immunology, Chang Gung University, Taoyuan, Taiwan."},{"name":"Laboratory of Human Immunology and Infectious Diseases, Graduate Institute of Clinical Medical Sciences, Chang Gung University, Taoyuan, Taiwan."},{"name":"Ludwig Institute of Cancer Research, University of Lausanne, Lausanne, Switzerland."},{"name":"Department of Fundamental Oncology, University of Lausanne, Lausanne, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5092-7774","authenticated-orcid":true,"given":"Jing-Ya","family":"Ding","sequence":"additional","affiliation":[{"name":"Center for Molecular and Clinical Immunology, Chang Gung University, Taoyuan, Taiwan."},{"name":"Laboratory of Human Immunology and Infectious Diseases, Graduate Institute of Clinical Medical Sciences, Chang Gung University, Taoyuan, Taiwan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0056-7440","authenticated-orcid":true,"given":"Yingxi","family":"Xu","sequence":"additional","affiliation":[{"name":"Ludwig Institute of Cancer Research, University of Lausanne, Lausanne, Switzerland."},{"name":"Department of Fundamental Oncology, University of Lausanne, Lausanne, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2247-5467","authenticated-orcid":true,"given":"Han-Po","family":"Shih","sequence":"additional","affiliation":[{"name":"Center for Molecular and Clinical Immunology, Chang Gung University, Taoyuan, Taiwan."},{"name":"Laboratory of Human Immunology and Infectious Diseases, Graduate Institute of Clinical Medical Sciences, Chang Gung University, Taoyuan, Taiwan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9063-6453","authenticated-orcid":true,"given":"You-Ning","family":"Lin","sequence":"additional","affiliation":[{"name":"Center for Molecular and Clinical Immunology, Chang Gung University, Taoyuan, Taiwan."},{"name":"Laboratory of Human Immunology and Infectious Diseases, Graduate Institute of Clinical Medical Sciences, Chang Gung 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Taiwan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-4442-2676","authenticated-orcid":true,"given":"Chia-Chi","family":"Lo","sequence":"additional","affiliation":[{"name":"Center for Molecular and Clinical Immunology, Chang Gung University, Taoyuan, Taiwan."},{"name":"Laboratory of Human Immunology and Infectious Diseases, Graduate Institute of Clinical Medical Sciences, Chang Gung University, Taoyuan, Taiwan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chu-Fu","family":"Yeh","sequence":"additional","affiliation":[{"name":"Laboratory of Human Immunology and Infectious Diseases, Graduate Institute of Clinical Medical Sciences, Chang Gung University, Taoyuan, Taiwan."},{"name":"Division of Infectious Diseases, Department of Internal Medicine, Linkou Chang Gung Memorial Hospital, Taoyuan, Taiwan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen-Yen","family":"Kuo","sequence":"additional","affiliation":[{"name":"Laboratory of Human Immunology and Infectious Diseases, Graduate Institute of Clinical Medical Sciences, Chang Gung University, Taoyuan, Taiwan."},{"name":"Division of Infectious Diseases, Department of Pediatrics, Chang Gung Memorial Hospital, Taoyuan, Taiwan."},{"name":"School of Traditional Chinese Medicine, College of Medicine, Chang Gung University, Taoyuan, Taiwan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7146-4481","authenticated-orcid":true,"given":"Kun-Hua","family":"Tu","sequence":"additional","affiliation":[{"name":"Center for Molecular and Clinical Immunology, Chang Gung University, Taoyuan, Taiwan."},{"name":"Department of Nephrology, Chang Gung Memorial Hospital, Taoyuan, Taiwan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1514-3015","authenticated-orcid":true,"given":"Shang-Yu","family":"Wang","sequence":"additional","affiliation":[{"name":"Laboratory of Human Immunology and Infectious Diseases, Graduate Institute of Clinical Medical Sciences, Chang Gung University, Taoyuan, Taiwan."},{"name":"Division of General Surgery, Department of Surgery, Chang Gung Memorial Hospital, Taoyuan, Taiwan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1677-8901","authenticated-orcid":true,"given":"Wei-Te","family":"Lei","sequence":"additional","affiliation":[{"name":"Laboratory of Human Immunology and Infectious Diseases, Graduate Institute of Clinical Medical Sciences, Chang Gung University, Taoyuan, Taiwan."},{"name":"Department of Pediatrics, Division of Pediatric Allergy, Immunology, and Rheumatology, Hsinchu Municipal MacKay Children\u2019s Hospital, Hsinchu, 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