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In early life, clonally diverse V\u03b41 subsets predominate across blood and tissues, comprising na\u00efve and differentiated effector and tissue repair functions, whereas cytolytic V\u03b42 subsets populate blood, spleen, and lungs. With age, V\u03b41 and V\u03b42 subsets exhibit clonal expansions and elevated cytolytic signatures, which are disseminated across sites. In adults, V\u03b42 cells predominate in blood, whereas V\u03b41 cells are enriched across tissues and express residency profiles. Thus, antigenic exposures over childhood drive the functional evolution and tissue compartmentalization of \u03b3\u03b4 T cells, leading to age-dependent roles in immunity.<\/jats:p>","DOI":"10.1126\/sciimmunol.adn3954","type":"journal-article","created":{"date-parts":[[2024,6,7]],"date-time":"2024-06-07T17:59:06Z","timestamp":1717783146000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":106,"title":["Human \u03b3\u03b4 T cells in diverse tissues exhibit site-specific maturation dynamics across the life span"],"prefix":"10.1126","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2796-5470","authenticated-orcid":true,"given":"Joshua I.","family":"Gray","sequence":"first","affiliation":[{"name":"Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY 10032 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