{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T13:14:25Z","timestamp":1792588465507,"version":"4.5.0"},"reference-count":72,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"106","content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Sci. Immunol."],"published-print":{"date-parts":[[2025,4,18]]},"abstract":"<jats:p>\n            Regulatory T (T\n            <jats:sub>reg<\/jats:sub>\n            ) cells play a vital role in maintaining maternal immune tolerance to the semiallogeneic fetus during pregnancy. T\n            <jats:sub>reg<\/jats:sub>\n            cell population heterogeneity and tissue-specific functions in the human decidua remain largely unknown. Here, using single-cell transcriptomic and T cell receptor sequencing of human CD4\n            <jats:sup>+<\/jats:sup>\n            T cells from first-trimester deciduae and matched peripheral blood of pregnant women, we identified a highly activated, immunosuppressive CCR8\n            <jats:sup>+<\/jats:sup>\n            T\n            <jats:sub>reg<\/jats:sub>\n            cell subset specifically enriched in the decidua (dT\n            <jats:sub>reg<\/jats:sub>\n            cells). CCR8\n            <jats:sup>+<\/jats:sup>\n            dT\n            <jats:sub>reg<\/jats:sub>\n            cells were decreased in patients with recurrent pregnancy loss (RPL) and an abortion-prone mouse model. Depletion of CCR8\n            <jats:sup>+<\/jats:sup>\n            dT\n            <jats:sub>reg<\/jats:sub>\n            cells increased susceptibility to fetal loss, with altered decidual immune profiles. Adoptive transfer of CCR8\n            <jats:sup>+<\/jats:sup>\n            T\n            <jats:sub>reg<\/jats:sub>\n            cells rescued fetal loss in abortion-prone mice. The CCR8 ligand CCL1 was mainly produced by decidual CD49a\n            <jats:sup>+<\/jats:sup>\n            natural killer cells and was significantly decreased in patients with RPL. Our data demonstrate that CCR8\n            <jats:sup>+<\/jats:sup>\n            dT\n            <jats:sub>reg<\/jats:sub>\n            cells are required to maintain maternal-fetal tolerance and highlight potential avenues for RPL therapies.\n          <\/jats:p>","DOI":"10.1126\/sciimmunol.ado2463","type":"journal-article","created":{"date-parts":[[2025,4,18]],"date-time":"2025-04-18T17:58:11Z","timestamp":1744999091000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":34,"title":["CCR8\n            <sup>+<\/sup>\n            decidual regulatory T cells maintain maternal-fetal immune tolerance during early pregnancy"],"prefix":"10.1126","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-6092-0551","authenticated-orcid":true,"given":"Zhuqing","family":"Li","sequence":"first","affiliation":[{"name":"State Key Laboratory of Reproductive Medicine and Offspring Health, Center for Reproductive Medicine, Institute of Women, Children and Reproductive Health, Second Hospital, Shandong University, Jinan, Shandong 250012, China."},{"name":"National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Shandong University, Jinan, Shandong 250012, China."},{"name":"Key Laboratory of Reproductive Endocrinology (Shandong University), Ministry of Education, Jinan, Shandong 250012, China."},{"name":"Shandong Technology Innovation Center for Reproductive Health, Jinan, Shandong 250012, China."},{"name":"Shandong Provincial Clinical Research Center for Reproductive Health, Jinan, Shandong 250012, China."},{"name":"Shandong Key Laboratory of Reproductive Research and Birth Defect Prevention, Jinan, Shandong 250012, China."},{"name":"Research Unit of Gametogenesis and Health of ART-Offspring, Chinese Academy of Medical Sciences (No. 2021RU001), Jinan, Shandong 250012, China."},{"name":"Department of Reproductive Medicine, Department of Obstetrics and Gynecology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong 250021, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-4942-4168","authenticated-orcid":true,"given":"Pinxin","family":"Si","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Reproductive Medicine and Offspring Health, Center for Reproductive Medicine, Institute of Women, Children and Reproductive Health, Second Hospital, Shandong University, Jinan, Shandong 250012, China."},{"name":"National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Shandong University, Jinan, Shandong 250012, China."},{"name":"Key Laboratory of Reproductive Endocrinology (Shandong University), Ministry of Education, Jinan, Shandong 250012, China."},{"name":"Shandong Technology Innovation Center for Reproductive Health, Jinan, Shandong 250012, China."},{"name":"Shandong Provincial Clinical Research Center for Reproductive Health, Jinan, Shandong 250012, China."},{"name":"Shandong Key Laboratory of Reproductive Research and Birth Defect Prevention, Jinan, Shandong 250012, China."},{"name":"Research Unit of Gametogenesis and Health of ART-Offspring, Chinese Academy of Medical Sciences (No. 2021RU001), Jinan, Shandong 250012, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-4625-3649","authenticated-orcid":true,"given":"Tingting","family":"Meng","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Reproductive Medicine and Offspring Health, Center for Reproductive Medicine, Institute of Women, Children and Reproductive Health, Second Hospital, Shandong University, Jinan, Shandong 250012, China."},{"name":"National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Shandong University, Jinan, Shandong 250012, China."},{"name":"Key Laboratory of Reproductive Endocrinology (Shandong University), Ministry of 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