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Thymic cortex and medulla epithelia displayed distinctive interferon-responsive signatures defined by lineage-specific chromatin accessibility. We explored the effects of type I and II interferons on thymic epithelial progenitor differentiation from induced pluripotent stem cells. Type II interferon was essential for expressing proteasome and antigen-presenting molecules, whereas type I or II interferons were essential for inducing different cytokines in thymic epithelial progenitor cells. Our findings suggest that interferons are critical to cortical and medullary thymic epithelial cell differentiation.<\/jats:p>","DOI":"10.1126\/sciimmunol.ado4720","type":"journal-article","created":{"date-parts":[[2025,5,2]],"date-time":"2025-05-02T13:58:53Z","timestamp":1746194333000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":12,"title":["Distinct type I and II interferon responses direct cortical and medullary thymic epithelial cell development"],"prefix":"10.1126","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-1717-5572","authenticated-orcid":true,"given":"Abdulvasey","family":"Mohammed","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Division of Hematology, Oncology, Stem Cell Transplantation, and Regenerative Medicine, Stanford School of Medicine, Stanford, CA 94304, 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