{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T13:30:42Z","timestamp":1791379842126,"version":"4.3.3"},"reference-count":73,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"105","content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Sci. Immunol."],"published-print":{"date-parts":[[2025,3,7]]},"abstract":"<jats:p>\n            STING is an essential component of the innate immune system, yet homeostatic STING expression patterns and regulation are unknown. Using\n            <jats:italic>\n              Sting1\n              <jats:sup>IRES-EGFP<\/jats:sup>\n            <\/jats:italic>\n            reporter and conditional\n            <jats:italic>Sting1<\/jats:italic>\n            transgenic mice, we found that regulation of STING expression is critical for immune cell development and functionality. STING expression was repressed in neutrophils, and forced STING expression or signaling drove systemic inflammatory disease. During T lymphocyte development, STING expression was restricted at the double-positive stage via epigenetic silencing by DNA methyltransferase 1. Forced STING expression or signaling impaired T lymphocyte development independent of type I interferon and promoted lineage commitment to innate-like \u03b3\u03b4 T cells over adaptive \u03b1\u03b2 T cells. In the tumor microenvironment, CD8\n            <jats:sup>+<\/jats:sup>\n            T lymphocytes repressed STING expression, correlating with features of T cell exhaustion in syngeneic mouse tumors and human colorectal cancer. Our data demonstrate the necessity of controlled, rather than ubiquitous, STING expression, uncovering a previously unappreciated dimension of STING pathobiology.\n          <\/jats:p>","DOI":"10.1126\/sciimmunol.ado9933","type":"journal-article","created":{"date-parts":[[2025,3,7]],"date-time":"2025-03-07T18:58:32Z","timestamp":1741373912000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":24,"title":["Dynamic STING repression orchestrates immune cell development and function"],"prefix":"10.1126","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3874-1691","authenticated-orcid":true,"given":"Kennady","family":"Knox","sequence":"first","affiliation":[{"name":"Department of Immunology, University of Texas Southwestern Medical Center, Dallas, TX, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5338-3477","authenticated-orcid":true,"given":"Devon","family":"Jeltema","sequence":"additional","affiliation":[{"name":"Department of Immunology, University of Texas Southwestern Medical Center, Dallas, TX, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1944-9740","authenticated-orcid":true,"given":"Nicole","family":"Dobbs","sequence":"additional","affiliation":[{"name":"Department of Immunology, University of Texas Southwestern Medical Center, Dallas, TX, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2011-7084","authenticated-orcid":true,"given":"Kun","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Immunology, University of Texas Southwestern Medical Center, Dallas, TX, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9641-335X","authenticated-orcid":true,"given":"Cong","family":"Xing","sequence":"additional","affiliation":[{"name":"Department of Immunology, University of Texas Southwestern Medical Center, Dallas, TX, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Immunology, University of Texas Southwestern Medical Center, Dallas, TX, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Immunology, University of Texas Southwestern Medical Center, Dallas, TX, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-7917-8961","authenticated-orcid":true,"given":"Gustavo","family":"Torres-Ramirez","sequence":"additional","affiliation":[{"name":"Department of Immunology, University of Texas Southwestern Medical Center, Dallas, TX, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6164-342X","authenticated-orcid":true,"given":"Jiefu","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Immunology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, National Key Laboratory of Druggability Evaluation and Systematic Translational Medicine, Tianjin 300060, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shan","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Immunology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, National Key Laboratory of Druggability Evaluation and Systematic Translational Medicine, Tianjin 300060, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4003-1034","authenticated-orcid":true,"given":"Tuoqi","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Immunology, University of Texas Southwestern Medical Center, Dallas, TX, USA."},{"name":"Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6852-5661","authenticated-orcid":true,"given":"Chen","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of Immunology, University of Texas Southwestern Medical Center, Dallas, TX, USA."},{"name":"Kidney Cancer Program, Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9286-2809","authenticated-orcid":true,"given":"Jian","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Immunology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, National Key Laboratory of Druggability Evaluation and Systematic Translational Medicine, Tianjin 300060, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0637-3989","authenticated-orcid":true,"given":"Nan","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Immunology, University of Texas Southwestern Medical Center, Dallas, TX, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1601999"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2020.06.009"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20161674"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-00573-w"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.15252\/embr.202255536"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20182192"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.26508\/lsa.201800282"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1516465112"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2011.11.018"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.24.15.6719-6727.2004"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1600722"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1312625"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1818281116"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2020.11.007"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2018.04.034"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2020.107771"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2019.01.044"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20171351"},{"key":"e_1_3_2_20_2","doi-asserted-by":"crossref","unstructured":"K. M. Gao K. N\u00fcndel K. Chiang X. Yin P. J. Utz K. Fitzgerald A. Marshak-Rothstein Activation of autoreactive lymphocytes in the lung by STING gain-of-function mutation radioresistant cells. bioRxiv 551002 [Preprint] (2023). https:\/\/doi.org\/10.1101\/2023.07.28.551002.","DOI":"10.1101\/2023.07.28.551002"},{"key":"e_1_3_2_21_2","doi-asserted-by":"crossref","unstructured":"K. M. Gao K. Chiang F. T. Korkmaz H. P. Janardhan C. M. Trivedi L. J. Quinton S. Gingras K. A. Fitzgerald A. Marshak-Rothstein Expression of a STING gain-of-function mutation in endothelial cells initiates lymphocytic infiltration of the lungs. bioRxiv 550897 [Preprint] (2023). https:\/\/doi.org\/10.1101\/2023.07.27.550897.","DOI":"10.1101\/2023.07.27.550897"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2202327119"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2625-x"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.202106046"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-018-0448-9"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2118819119"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.09.020"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-03762-2"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aay9013"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-18278-6"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2021.05.008"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.3390\/cancers15133510"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2022.09.002"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.13183"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00262-022-03270-w"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2013598118"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-37217-1"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2022.114033"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1136\/jitc-2021-002528"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-022-01093-w"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1158\/2326-6066.CIR-19-0229"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41388-017-0120-0"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature07317"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1229963"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3117"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2016.03.017"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri3660"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-15-1885"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1701405"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni1008-1091"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1260419"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.2006134"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2021.02.005"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrd2180"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.1038\/s43018-021-00249-x"},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2023.09.006"},{"key":"e_1_3_2_57_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-022-01152-y"},{"key":"e_1_3_2_58_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-023-01685-w"},{"key":"e_1_3_2_59_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41420-023-01663-z"},{"key":"e_1_3_2_60_2","doi-asserted-by":"crossref","unstructured":"J. Zhu X. Ruan M. C. Mangione P. Parra X. Su X. Luo D. J. Cao The cGAS-STING pathway is essential in acute ischemia-induced neutropoiesis and neutrophil priming in the bone marrow. bioRxiv 604120 [Preprint] (2024). https:\/\/doi.org\/10.1101\/2024.07.18.604120.","DOI":"10.1101\/2024.07.18.604120"},{"key":"e_1_3_2_61_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri2820"},{"key":"e_1_3_2_62_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20072425"},{"key":"e_1_3_2_63_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2005.03.014"},{"key":"e_1_3_2_64_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-032713-120216"},{"key":"e_1_3_2_65_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2018.04.117"},{"key":"e_1_3_2_66_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-018-0287-8"},{"key":"e_1_3_2_67_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20030584"},{"key":"e_1_3_2_68_2","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/5081634"},{"key":"e_1_3_2_69_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri3384"},{"key":"e_1_3_2_70_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20170686"},{"key":"e_1_3_2_71_2","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-22-2235"},{"key":"e_1_3_2_72_2","doi-asserted-by":"publisher","DOI":"10.1002\/0471142735.im0320s110"},{"key":"e_1_3_2_73_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.xpro.2021.100948"},{"key":"e_1_3_2_74_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jim.2022.113403"}],"container-title":["Science Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/sciimmunol.ado9933","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T17:58:46Z","timestamp":1741802326000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/sciimmunol.ado9933"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,7]]},"references-count":73,"journal-issue":{"issue":"105","published-print":{"date-parts":[[2025,3,7]]}},"alternative-id":["10.1126\/sciimmunol.ado9933"],"URL":"https:\/\/doi.org\/10.1126\/sciimmunol.ado9933","relation":{},"ISSN":["2470-9468"],"issn-type":[{"value":"2470-9468","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,7]]},"assertion":[{"value":"2024-03-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-15","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-17","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-07","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"eado9933"}}