{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T18:33:26Z","timestamp":1788287606633,"version":"build-2803163510"},"reference-count":66,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"97","content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Sci. Immunol."],"published-print":{"date-parts":[[2024,7,26]]},"abstract":"<jats:p>\n            Type I and III interferons (IFNs) are robustly induced during infections and protect cells against viral infection. Both type I and III IFNs are also produced at low levels in the thymus at steady state; however, their role in T cell development and immune tolerance is unclear. Here, we found that both type I and III IFNs were constitutively produced by a very small number of AIRE\n            <jats:sup>+<\/jats:sup>\n            murine thymic epithelial cells, independent of microbial stimulation. Antigen-presenting cells were highly responsive to thymic IFNs, and IFNs were required for the activation and maturation of thymic type 1 conventional dendritic cells, macrophages, and B cells. Loss of IFN sensing led to reduced regulatory T cell selection, reduced T cell receptor (TCR) repertoire diversity, and enhanced autoreactive T cell responses to self-antigens expressed during peripheral IFN signaling. Thus, constitutive exposure to IFNs in the thymus is required for generating a tolerant and diverse TCR repertoire.\n          <\/jats:p>","DOI":"10.1126\/sciimmunol.adp1139","type":"journal-article","created":{"date-parts":[[2024,7,26]],"date-time":"2024-07-26T18:00:45Z","timestamp":1722016845000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":50,"title":["Sterile production of interferons in the thymus affects T cell repertoire selection"],"prefix":"10.1126","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6297-5941","authenticated-orcid":true,"given":"K. 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