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Whereas it presented reduced toxicities compared with those commonly associated with T cell therapies, CD20-NKCE-IL2v showed greater killing efficacy over a T cell engager targeting CD20 in in vitro preclinical models. CD20-NKCE-IL2v also increased the cell surface expression of NK cell\u2013activating receptors, leading to activity against CD20-negative tumor cells. In vivo studies in nonhuman primates and tumor mouse models further validated its efficacy and revealed that CD20-NKCE-IL2v induces peripheral NK cell homing at the tumor site. CD20-NKCE-IL2v emerges as a potential alternative in the treatment landscape of B-NHL.<\/jats:p>","DOI":"10.1126\/sciimmunol.adp3720","type":"journal-article","created":{"date-parts":[[2024,11,15]],"date-time":"2024-11-15T18:58:23Z","timestamp":1731697103000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":20,"title":["A tetraspecific engager armed with a non-alpha IL-2 variant harnesses natural killer cells against B cell non-Hodgkin lymphoma"],"prefix":"10.1126","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5690-5763","authenticated-orcid":true,"given":"Olivier","family":"Demaria","sequence":"first","affiliation":[{"name":"Innate Pharma Research Laboratories, Innate Pharma, Marseille, 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