{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T11:01:21Z","timestamp":1788865281513,"version":"build-2803163510"},"reference-count":100,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"111","content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Sci. Immunol."],"published-print":{"date-parts":[[2025,9,26]]},"abstract":"<jats:p>The peripheral nervous system (PNS) is involved in nociception and gait. The contribution of PNS-resident immune cells to these functions is not fully understood. We identified group 2 innate lymphoid cells (ILC2s) as a distinct immune cell population resident in the PNS, with a unique gene profile facilitating neuron-ILC2 cross-talk. ILC2-deficient mice display PNS dysfunction (hypersensitivity and gait anomalies). These functional deficits are attributed to structural abnormalities in the sciatic nerves of ILC2-deficient mice. ILC2s communicate with dorsal root ganglion neurons via the interleukin-13 (IL-13) signaling pathway to maintain nerve structure and pain thresholds. Loss of the shared IL-4\/IL-13 receptor (IL-4R\/IL-13R) in neurons results in a phenotype similar to ILC2-deficient mice. Intrathecally administered IL-13 rescues hypersensitivity and gait defects in ILC2-deficient mice, which suggests that this signaling pathway may be therapeutically important. This work therefore identifies a function for ILC2s in regulating the nerve structural integrity and nociceptive functions of the PNS.<\/jats:p>","DOI":"10.1126\/sciimmunol.adp7092","type":"journal-article","created":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T17:58:23Z","timestamp":1758909503000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":9,"title":["Group 2 innate lymphoid cells regulate nociceptive and gait functions of the peripheral nervous system"],"prefix":"10.1126","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9166-2509","authenticated-orcid":true,"given":"Divija","family":"Deshpande","sequence":"first","affiliation":[{"name":"Department of Microbiology, Infectious Diseases and Immunology, Charit\u00e9\u2013Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-7347-8067","authenticated-orcid":true,"given":"Laura","family":"Velleman","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Infectious Diseases and Immunology, Charit\u00e9\u2013Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-0195-1661","authenticated-orcid":true,"given":"Janna","family":"Schmitz","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Infectious Diseases and Immunology, Charit\u00e9\u2013Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9688-0203","authenticated-orcid":true,"given":"Patrycja M.","family":"Forster","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Infectious Diseases and Immunology, Charit\u00e9\u2013Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0199-9672","authenticated-orcid":true,"given":"Christian","family":"Schinke","sequence":"additional","affiliation":[{"name":"Klinik und Hochschulambulanz f\u00fcr Neurologie, Charit\u00e9\u2013Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany."},{"name":"Berlin Institute of Health at Charit\u00e9, Universit\u00e4tsmedizin Berlin, Berlin, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5520-4164","authenticated-orcid":true,"given":"Sotiria","family":"Boulekou","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Infectious Diseases and Immunology, Charit\u00e9\u2013Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0805-4084","authenticated-orcid":true,"given":"Henning Peter","family":"D\u00fcsedau","sequence":"additional","affiliation":[{"name":"Institute of Inflammation and Neurodegeneration, Otto-von-Guericke University Magdeburg, Magdeburg, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1293-2484","authenticated-orcid":true,"given":"Susanne M.","family":"Krug","sequence":"additional","affiliation":[{"name":"Clinical Physiology\/Nutritional Medicine, Charit\u00e9\u2013Universit\u00e4tsmedizin Berlin, Berlin, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-5605-6352","authenticated-orcid":true,"given":"Till","family":"Mertens","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Clinical Immunology, Charit\u00e9\u2013Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany."},{"name":"Deutsches Rheuma-Forschungszentrum (DRFZ), an Institute of the Leibniz Association, Berlin, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2949-3609","authenticated-orcid":true,"given":"Xuemei","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Infectious Diseases and Immunology, Charit\u00e9\u2013Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1517-5957","authenticated-orcid":true,"given":"Caio","family":"Figueiredo","sequence":"additional","affiliation":[{"name":"Institute of Inflammation and Neurodegeneration, Otto-von-Guericke University Magdeburg, Magdeburg, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5162-7266","authenticated-orcid":true,"given":"Katja J.","family":"Jarick","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Infectious Diseases and Immunology, Charit\u00e9\u2013Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7811-4476","authenticated-orcid":true,"given":"Thomas","family":"Plum","sequence":"additional","affiliation":[{"name":"Division for Cellular Immunology, German Cancer Research Center, Heidelberg, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-9052-1135","authenticated-orcid":true,"given":"Nele","family":"Sterczyk","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Infectious Diseases and Immunology, Charit\u00e9\u2013Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1794-9461","authenticated-orcid":true,"given":"Pierre S.","family":"Lecl\u00e8re","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Infectious Diseases and Immunology, Charit\u00e9\u2013Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9087-2958","authenticated-orcid":true,"given":"Sofia","family":"Helfrich","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Infectious Diseases and Immunology, Charit\u00e9\u2013Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9343-7580","authenticated-orcid":true,"given":"Anke","family":"Tappe-Theodor","sequence":"additional","affiliation":[{"name":"Institute of Pharmacology, Heidelberg University, Heidelberg, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katja","family":"Kotsch","sequence":"additional","affiliation":[{"name":"Department for General and Visceral Surgery, Charit\u00e9\u2013Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0647-4157","authenticated-orcid":true,"given":"Johannes","family":"Steffen","sequence":"additional","affiliation":[{"name":"Institute of Inflammation and Neurodegeneration, Otto-von-Guericke University Magdeburg, Magdeburg, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6650-0639","authenticated-orcid":true,"given":"David","family":"Voehringer","sequence":"additional","affiliation":[{"name":"Department of Infection Biology, University Hospital Erlangen and Friedrich-Alexander University Erlangen-Nuremberg (FAU), Erlangen, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5010-3994","authenticated-orcid":true,"given":"Claudia U.","family":"Duerr","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Infectious Diseases and Immunology, Charit\u00e9\u2013Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7725-9526","authenticated-orcid":true,"given":"Anja E.","family":"Hauser","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Clinical Immunology, Charit\u00e9\u2013Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany."},{"name":"Deutsches Rheuma-Forschungszentrum (DRFZ), an Institute of the Leibniz Association, Berlin, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1753-4100","authenticated-orcid":true,"given":"David","family":"Artis","sequence":"additional","affiliation":[{"name":"Jill Roberts Institute for Research in Inflammatory Bowel Disease, Joan and Sanford I. Weill Department of Medicine, Department of Microbiology and Immunology, Weill Cornell Medicine, Cornell University, New York, NY, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7663-1031","authenticated-orcid":true,"given":"Claudia","family":"Pitzer","sequence":"additional","affiliation":[{"name":"Interdisciplinary Neurobehavioral Core, Ruprecht-Karls-Universit\u00e4t Heidelberg, Heidelberg, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ildiko R.","family":"Dunay","sequence":"additional","affiliation":[{"name":"Institute of Inflammation and Neurodegeneration, Otto-von-Guericke University Magdeburg, Magdeburg, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8803-2979","authenticated-orcid":true,"given":"Christoph S. N.","family":"Klose","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Infectious Diseases and Immunology, Charit\u00e9\u2013Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0004.2007.00790.x"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.neuro.051508.135531"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.4239\/wjd.v6.i3.432"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2007.08.024"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2017.2"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(14)70102-4"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.3390\/biom5043416"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3212-17.2018"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI86812"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-20677-0"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2015.04.017"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-03151-1"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.imlet.2021.10.001"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.08.006"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1900-1"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20161982"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20190915"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2022.110564"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature12526"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41385-022-00516-9"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2015.06.007"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature23676"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature23469"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature24029"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2019.09.005"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2019.06.009"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2019.09.004"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2022.12.017"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-022-05395-5"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-022-05297-6"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2012.06.020"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature20105"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3078"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-022-04777-z"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1038\/nn.4053"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1038\/nn.4549"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm.4329"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1177\/1744806916656635"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1501372112"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1111\/bph.15176"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-12771-8"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000000917"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1186\/1744-8069-7-4"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1097\/PR9.0000000000000564"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1038\/39807"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2012.08.018"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/9861459"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1186\/1744-8069-10-73"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11302-004-4740-9"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0702319"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.21-17-06522.2001"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(00)80294-0"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.183.1.195"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-45261-8"},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20091419"},{"key":"e_1_3_2_57_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature18626"},{"key":"e_1_3_2_58_2","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000001528"},{"key":"e_1_3_2_59_2","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.1.51.pe55"},{"key":"e_1_3_2_60_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aai8132"},{"key":"e_1_3_2_61_2","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.aaw2938"},{"key":"e_1_3_2_62_2","doi-asserted-by":"publisher","DOI":"10.1097\/WCO.0000000000001116"},{"key":"e_1_3_2_63_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2015.07.013"},{"key":"e_1_3_2_64_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-019-0092-1"},{"key":"e_1_3_2_65_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aam6072"},{"key":"e_1_3_2_66_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2016.00369"},{"key":"e_1_3_2_67_2","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000001986"},{"key":"e_1_3_2_68_2","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.adf9535"},{"key":"e_1_3_2_69_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-03151-1"},{"key":"e_1_3_2_70_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri.2016.123"},{"key":"e_1_3_2_71_2","doi-asserted-by":"publisher","DOI":"10.1038\/35094583"},{"key":"e_1_3_2_72_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-021-00508-z"},{"key":"e_1_3_2_73_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2021.10.022"},{"key":"e_1_3_2_74_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20211887"},{"key":"e_1_3_2_75_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-35806-8"},{"key":"e_1_3_2_76_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1601546"},{"key":"e_1_3_2_77_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2021.06.015"},{"key":"e_1_3_2_78_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2019.01.012"},{"key":"e_1_3_2_79_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaf8924"},{"key":"e_1_3_2_80_2","doi-asserted-by":"publisher","DOI":"10.1177\/2058738419838383"},{"key":"e_1_3_2_81_2","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000002461"},{"key":"e_1_3_2_82_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40122-017-0091-4"},{"key":"e_1_3_2_83_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncb2490"},{"key":"e_1_3_2_84_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.02184"},{"key":"e_1_3_2_85_2","doi-asserted-by":"publisher","DOI":"10.3389\/fncir.2014.00076"},{"key":"e_1_3_2_86_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(04)00107-4"},{"key":"e_1_3_2_87_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-9822(98)70256-8"},{"key":"e_1_3_2_88_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2015.05.018"},{"key":"e_1_3_2_89_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-213X-1-4"},{"key":"e_1_3_2_90_2","doi-asserted-by":"publisher","DOI":"10.1038\/nn.2467"},{"key":"e_1_3_2_91_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2012.10.011"},{"key":"e_1_3_2_92_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200636745"},{"key":"e_1_3_2_93_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1003988107"},{"key":"e_1_3_2_94_2","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(88)90026-7"},{"key":"e_1_3_2_95_2","first-page":"e51229","article-title":"In vivo SiRNA transfection and gene knockdown in spinal cord via rapid noninvasive lumbar intrathecal injections in mice","volume":"85","author":"Njoo C.","year":"2014","unstructured":"C. Njoo, C. Heinl, R. Kuner, In vivo SiRNA transfection and gene knockdown in spinal cord via rapid noninvasive lumbar intrathecal injections in mice. J. Vis. Exp. 85, e51229 (2014).","journal-title":"J. Vis. Exp."},{"key":"e_1_3_2_96_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2016.10.022"},{"key":"e_1_3_2_97_2","doi-asserted-by":"publisher","DOI":"10.1523\/ENEURO.0049-14.2014"},{"key":"e_1_3_2_98_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1130933"},{"key":"e_1_3_2_99_2","doi-asserted-by":"publisher","DOI":"10.3390\/molecules23020346"},{"key":"e_1_3_2_100_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.01776-21"},{"key":"e_1_3_2_101_2","unstructured":"L. Velleman J. Schmitz \u201cIllustrations from the ILC2 paper by Deshpande et al. (Science Immunology 2025)\u201d (BioRender 2025); https:\/\/BioRender.com\/rb9p22c."}],"container-title":["Science Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/sciimmunol.adp7092","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T17:58:29Z","timestamp":1758909509000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/sciimmunol.adp7092"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,26]]},"references-count":100,"journal-issue":{"issue":"111","published-print":{"date-parts":[[2025,9,26]]}},"alternative-id":["10.1126\/sciimmunol.adp7092"],"URL":"https:\/\/doi.org\/10.1126\/sciimmunol.adp7092","relation":{},"ISSN":["2470-9468"],"issn-type":[{"value":"2470-9468","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,26]]},"assertion":[{"value":"2024-04-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-28","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-26","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"eadp7092"}}