{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T23:46:51Z","timestamp":1792453611359,"version":"4.5.0"},"reference-count":46,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"105","license":[{"start":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T00:00:00Z","timestamp":1773446400000},"content-version":"vor","delay-in-days":365,"URL":"https:\/\/www.science.org\/content\/page\/science-licenses-journal-article-reuse"}],"content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Sci. Immunol."],"published-print":{"date-parts":[[2025,3,14]]},"abstract":"<jats:p>\n            Regulatory T cells (T\n            <jats:sub>regs<\/jats:sub>\n            ) have diverse functional specification in homeostasis and disease. However, how liver T\n            <jats:sub>regs<\/jats:sub>\n            function and are transcriptionally regulated in obesity is not well understood. Here, we identified that effector T\n            <jats:sub>regs<\/jats:sub>\n            expressing activating transcription factor 4 (ATF4) were enriched in the livers of obese mice. ATF4 was critical for driving an effector T\n            <jats:sub>reg<\/jats:sub>\n            transcriptional program, and ATF4-expressing T\n            <jats:sub>regs<\/jats:sub>\n            promoted the development of obesity-induced liver fibrosis by enhancing transforming growth factor\u2013\u03b2 activation via integrin \u03b1v\u03b28. T\n            <jats:sub>reg<\/jats:sub>\n            -specific deletion of\n            <jats:italic>Atf4<\/jats:italic>\n            resulted in reduced liver T\n            <jats:sub>regs<\/jats:sub>\n            and attenuation of obesity-induced liver abnormalities. Furthermore, ATF4 was required to promote the differentiation of nonlymphoid tissue T\n            <jats:sub>reg<\/jats:sub>\n            precursors under steady state. These findings demonstrate that ATF4 is important for regulating T\n            <jats:sub>reg<\/jats:sub>\n            functional specification in homeostasis and obesity.\n          <\/jats:p>","DOI":"10.1126\/sciimmunol.adp7193","type":"journal-article","created":{"date-parts":[[2025,3,14]],"date-time":"2025-03-14T17:59:21Z","timestamp":1741975161000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":15,"title":["ATF4 drives regulatory T cell functional specification in homeostasis and obesity"],"prefix":"10.1126","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-1657-0531","authenticated-orcid":true,"given":"Ke","family":"Wang","sequence":"first","affiliation":[{"name":"Division of Endocrinology and Metabolism, Department of Medicine, University of California, San Diego, La Jolla, CA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-4993-0364","authenticated-orcid":true,"given":"Andrea","family":"Farrell","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism, Department of Medicine, University of California, San Diego, La Jolla, CA, USA."},{"name":"School of Biological Sciences, University of California, San Diego, La Jolla, CA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3739-4934","authenticated-orcid":true,"given":"Enchen","family":"Zhou","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism, Department of Medicine, University of California, San Diego, La Jolla, CA, USA."},{"name":"Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Houji","family":"Qin","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism, Department of Medicine, University of California, San Diego, La Jolla, CA, USA."},{"name":"School of Biological Sciences, University of California, San Diego, La Jolla, CA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-6420-7098","authenticated-orcid":true,"given":"Zixuan","family":"Zeng","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism, Department of Medicine, University of California, San Diego, La Jolla, CA, USA."},{"name":"School of Biological Sciences, University of California, San Diego, La Jolla, CA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-3967-2791","authenticated-orcid":true,"given":"Kailun","family":"Zhou","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism, Department of Medicine, University of California, San Diego, La Jolla, CA, USA."},{"name":"School of Biological Sciences, University of California, San Diego, La Jolla, CA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karina","family":"Cunha e Rocha","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism, Department of Medicine, University of California, San Diego, La Jolla, CA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6291-0750","authenticated-orcid":true,"given":"Dinghong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism, Department of Medicine, University of California, San Diego, La Jolla, CA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaowei","family":"Wang","sequence":"additional","affiliation":[{"name":"Institute of Modern Biology, Nanjing University, Nanjing, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amha","family":"Atakilit","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of California, San Francisco, San Francisco, CA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6277-2036","authenticated-orcid":true,"given":"Dean","family":"Sheppard","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of California, San Francisco, San Francisco, CA, 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