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We show that the differences between first-trimester and term HBCs are important in the context of infection with\n            <jats:italic>Listeria monocytogenes<\/jats:italic>\n            , a pathogen that crosses the placenta and replicates within macrophages. Specifically, we observed reduced colony-forming units and diminished actin recruitment by\n            <jats:italic>L. monocytogenes<\/jats:italic>\n            in first-trimester HBCs compared with term HBCs. Our findings indicate that the ability of\n            <jats:italic>L. monocytogenes<\/jats:italic>\n            to escape from vacuoles is impaired within first-trimester HBCs. Thus, the changes in HBC biology across pregnancy are important in shaping their interactions with\n            <jats:italic>L. monocytogenes.<\/jats:italic>\n          <\/jats:p>","DOI":"10.1126\/sciimmunol.adq3066","type":"journal-article","created":{"date-parts":[[2025,7,18]],"date-time":"2025-07-18T17:58:50Z","timestamp":1752861530000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":14,"title":["Interactions between placental Hofbauer cells and\n            <i>L. monocytogenes<\/i>\n            change throughout gestation"],"prefix":"10.1126","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-5207-8282","authenticated-orcid":true,"given":"Nagisa","family":"Yoshida","sequence":"first","affiliation":[{"name":"Department of Pathology, University of Cambridge, Cambridge, UK."},{"name":"Loke Centre for Trophoblast Research, University of Cambridge, Cambridge, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7111-5126","authenticated-orcid":true,"given":"Anna","family":"Appios","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Cambridge, Cambridge, UK."},{"name":"Loke Centre for Trophoblast Research, University of Cambridge, Cambridge, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5381-8568","authenticated-orcid":true,"given":"Qian","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Cambridge, Cambridge, UK."},{"name":"Loke Centre for Trophoblast Research, University of Cambridge, Cambridge, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3013-2429","authenticated-orcid":true,"given":"Joseph P.","family":"Hutton","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Cambridge, Cambridge, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-3497-6329","authenticated-orcid":true,"given":"George","family":"Wood","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Cambridge, Cambridge, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6738-0066","authenticated-orcid":true,"given":"Martin","family":"Potts","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Cambridge, Cambridge, UK."},{"name":"Loke Centre for Trophoblast Research, University of Cambridge, Cambridge, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Aleksandrowicz","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Cambridge, Cambridge, UK."},{"name":"Loke Centre for Trophoblast Research, University of Cambridge, Cambridge, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6335-4354","authenticated-orcid":true,"given":"Enrico R.","family":"Barrozo","sequence":"additional","affiliation":[{"name":"Division of Maternal Fetal Medicine, Department of Obstetrics and Gynaecology, Baylor College of Medicine and Texas Children\u2019s Hospital, Houston, TX, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-8070-8659","authenticated-orcid":true,"given":"Freya","family":"Dover","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Cambridge, Cambridge, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-9721-0048","authenticated-orcid":true,"given":"Holly","family":"Anderson","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Cambridge, Cambridge, UK."},{"name":"Loke Centre for Trophoblast Research, University of Cambridge, Cambridge, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katie","family":"Stephens","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, NIHR Cambridge Biomedical Research Centre, University of Cambridge, Cambridge, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3400-5005","authenticated-orcid":true,"given":"Irving L. 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