{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T01:03:36Z","timestamp":1791939816117,"version":"4.3.4"},"reference-count":62,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"105","content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Sci. Immunol."],"published-print":{"date-parts":[[2025,3,21]]},"abstract":"<jats:p>\n            <jats:italic>Aspergillus fumigatus<\/jats:italic>\n            causes life-threatening mold pneumonia in immunocompromised patients, particularly in those with quantitative or qualitative defects in neutrophils. Whereas innate immune cell cross-talk licenses neutrophil antifungal activity in the lung, the role of epithelial cells in this process is unknown. Here, we find that surfactant protein C (SPC)\u2013expressing lung epithelial cells integrate infection-induced interleukin-1 and type III interferon signaling to produce granulocyte-macrophage colony-stimulating factor (GM-CSF) preferentially at local sites of fungal infection and neutrophil influx. Using in vivo models that distinguish the role of GM-CSF during acute infection from its homeostatic function in alveolar macrophage survival and surfactant catabolism, we demonstrate that epithelial-derived GM-CSF increases the accumulation and fungicidal activity of GM-CSF\u2013responsive neutrophils, which is essential for host survival. Our findings establish SPC\n            <jats:sup>+<\/jats:sup>\n            epithelial cells as a central player in regulating the quality and strength of neutrophil-dependent immunity against inhaled mold pathogens.\n          <\/jats:p>","DOI":"10.1126\/sciimmunol.adr0547","type":"journal-article","created":{"date-parts":[[2025,3,21]],"date-time":"2025-03-21T18:01:09Z","timestamp":1742580069000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":28,"title":["GM-CSF\u2013mediated epithelial-immune cell cross-talk orchestrates pulmonary immunity to\n            <i>Aspergillus fumigatus<\/i>"],"prefix":"10.1126","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6476-1023","authenticated-orcid":true,"given":"Kathleen A. 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