{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T23:16:10Z","timestamp":1792451770552,"version":"4.5.0"},"reference-count":77,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"109","content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Sci. Immunol."],"published-print":{"date-parts":[[2025,7,25]]},"abstract":"<jats:p>\n            Whereas visceral adipose tissue (VAT) primarily stores excess energy, brown adipose tissue (BAT) dissipates it in a process termed nonshivering thermogenesis. Several key VAT features, particularly murine epidydimal VAT, are regulated by a distinct population of regulatory T (T\n            <jats:sub>reg<\/jats:sub>\n            ) cells, raising the question of whether BAT hosts an analogous population. Although T\n            <jats:sub>reg<\/jats:sub>\n            cells have been observed in BAT, their properties and mechanisms of action require elucidation. We found BAT T\n            <jats:sub>reg<\/jats:sub>\n            cells to be heterogeneous in subtissular localization and subtype composition. Punctual depletion of T\n            <jats:sub>reg<\/jats:sub>\n            cells unleashed interferon-\u03b3 (IFN-\u03b3)\u2013producing lymphocytes in BAT, but not in subcutaneous or visceral fat depots, leading to IFN-\u03b3\u2013dependent mitochondrial dysfunction and metabolic dysregulation, thereby impeding nonshivering thermogenesis. Cold challenge selectively expanded the IL-18R1\n            <jats:sup>+<\/jats:sup>\n            T\n            <jats:sub>reg<\/jats:sub>\n            subtype in BAT; stripping this receptor specifically from T\n            <jats:sub>reg<\/jats:sub>\n            cells unleashed IFN-\u03b3\u2013producing lymphocytes and compromised temperature control. Thus, control of local IFN-\u03b3 production is a core feature of T\n            <jats:sub>reg<\/jats:sub>\n            cell control of tissue homeostasis.\n          <\/jats:p>","DOI":"10.1126\/sciimmunol.ads0478","type":"journal-article","created":{"date-parts":[[2025,7,25]],"date-time":"2025-07-25T17:58:07Z","timestamp":1753466287000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":12,"title":["Regulatory T cells in brown adipose tissue safeguard thermogenesis by restraining interferon-\u03b3\u2013producing lymphocytes"],"prefix":"10.1126","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3694-2951","authenticated-orcid":true,"given":"Nathan W.","family":"Zammit","sequence":"first","affiliation":[{"name":"Department of Immunology, Harvard Medical School, Boston, MA 02115, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3239-6022","authenticated-orcid":true,"given":"Ariana","family":"Vargas-Castillo","sequence":"additional","affiliation":[{"name":"Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02115, USA."},{"name":"Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. 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