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Here, we identify thrombospondin-1 (Thbs1) as an essential regulator of inflammaging within HSCs. We describe a transcriptomics-based approach for measuring inflammaging within stem cells and demonstrate that deletion of\n                    <jats:italic>Thbs1<\/jats:italic>\n                    is sufficient to prevent HSC inflammaging. Our results demonstrate that suppression of HSC inflammaging prevents aging-associated defects in hematopoietic activity including loss of HSC self-renewal, myeloid-biased HSC differentiation, and anemia. Our findings indicate that suppression of HSC inflammaging may also prolong overall systemic health span.\n                  <\/jats:p>","DOI":"10.1126\/sciimmunol.ads1556","type":"journal-article","created":{"date-parts":[[2025,1,3]],"date-time":"2025-01-03T13:58:21Z","timestamp":1735912701000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":22,"title":["Suppression of thrombospondin-1\u2013mediated inflammaging prolongs hematopoietic health span"],"prefix":"10.1126","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5943-9670","authenticated-orcid":true,"given":"Pradeep","family":"Ramalingam","sequence":"first","affiliation":[{"name":"Division of Hematology and Oncology, Department of Medicine, University of Florida, Gainesville, FL 32610, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-7906-1696","authenticated-orcid":true,"given":"Michael 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