{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T01:16:34Z","timestamp":1790385394389,"version":"4.1.0"},"reference-count":71,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"110","content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Sci. Immunol."],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:p>\n                    Influenza viruses are a major global cause of morbidity and mortality. Although vagal TRPV1\n                    <jats:sup>+<\/jats:sup>\n                    nociceptive sensory neurons are known to mediate defenses against harmful agents, including pathogens, their function in lung antiviral defenses remains unclear. Our study demonstrates that both systemic and vagal-specific ablation of TRPV1\n                    <jats:sup>+<\/jats:sup>\n                    nociceptors reduce survival in mice infected with influenza A virus (IAV). Despite no difference in viral load, mice lacking TRPV1\n                    <jats:sup>+<\/jats:sup>\n                    neurons exhibited increased viral spread, exacerbated lung pathology, and elevated levels of proinflammatory cytokines. Loss of TRPV1\n                    <jats:sup>+<\/jats:sup>\n                    neurons altered the lung immune landscape, including an expansion of neutrophils and monocyte-derived macrophages. Transcriptional analysis revealed impaired interferon signaling in myeloid cells and an imbalance in distinct neutrophil subpopulations in the absence of nociceptors. Furthermore, antibody-mediated depletion of myeloid cells during IAV infection substantially improved survival after nociceptor ablation, underscoring the role of TRPV1\n                    <jats:sup>+<\/jats:sup>\n                    neurons in preventing pathogenic myeloid cell states that contribute to IAV-induced mortality.\n                  <\/jats:p>","DOI":"10.1126\/sciimmunol.ads6243","type":"journal-article","created":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T17:58:56Z","timestamp":1754071136000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":21,"title":["Vagal TRPV1\n                    <sup>+<\/sup>\n                    sensory neurons protect against influenza virus infection by regulating lung myeloid cell dynamics"],"prefix":"10.1126","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9829-0402","authenticated-orcid":true,"given":"Nicole","family":"Almanzar","sequence":"first","affiliation":[{"name":"Department of Immunology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA."},{"name":"Department of Environmental Health, Harvard T.H. 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