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Most Apex bnAbs engage Env using an exceptionally long heavy-chain complementarity-determining region 3 (HCDR3) containing specific binding motifs, which reduces bnAb precursor frequency and makes priming of rare bnAb precursors a likely limiting step in the path to Apex bnAb induction. We found that adjuvanted protein or mRNA lipid nanoparticle (LNP) immunization of rhesus macaques with ApexGT6, an Env trimer engineered to bind Apex bnAb precursors, consistently induced Apex bnAb\u2013related precursors with long HCDR3s bearing bnAb-like sequence motifs. Cryo\u2013electron microscopy revealed that elicited Apex bnAb\u2013related HCDR3s had structures combining elements of several prototype Apex bnAbs. These results achieve a critical HIV vaccine development milestone in outbred primates.<\/jats:p>","DOI":"10.1126\/sciimmunol.adt6660","type":"journal-article","created":{"date-parts":[[2025,8,22]],"date-time":"2025-08-22T17:58:34Z","timestamp":1755885514000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":21,"title":["HIV broadly neutralizing antibody precursors to the Apex epitope induced in nonhuman primates"],"prefix":"10.1126","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6519-2531","authenticated-orcid":true,"given":"Krystal M.","family":"Ma","sequence":"first","affiliation":[{"name":"Consortium for HIV\/AIDS Vaccine Development (CHAVD), Scripps Research Institute, La Jolla, CA 92037, USA."},{"name":"IAVI Neutralizing Antibody Center, Scripps Research Institute, La Jolla, CA 92037, USA."},{"name":"Department of Immunology and Microbiology, Scripps Research Institute, La Jolla, CA 92037, 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