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A T\n                    <jats:sub>reg<\/jats:sub>\n                    subtype specialized in controlling interferon-\u03b3 (IFN-\u03b3) responses and another dedicated to regulating follicular B cell responses were substantial components of this compartment. Accordingly, punctual T\n                    <jats:sub>reg<\/jats:sub>\n                    ablation rapidly unleashed IFN-\u03b3 production by meningeal lymphocytes, unlocked access to the brain parenchyma, and altered meningeal B cell profiles. Distally, the hippocampus assumed a reactive state, with morphological and transcriptional changes in multiple glial cell types. Within the dentate gyrus, neural stem cells underwent more death and were blocked from further differentiation, which coincided with impairments in short-term spatial-reference memory. Thus, meningeal T\n                    <jats:sub>regs<\/jats:sub>\n                    are a multifaceted safeguard of brain homeostasis at steady state.\n                  <\/jats:p>","DOI":"10.1126\/sciimmunol.adu2910","type":"journal-article","created":{"date-parts":[[2025,1,28]],"date-time":"2025-01-28T09:59:19Z","timestamp":1738058359000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":71,"title":["The meninges host a distinct compartment of regulatory T cells that preserves brain homeostasis"],"prefix":"10.1126","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8659-7706","authenticated-orcid":true,"given":"Miguel","family":"Marin-Rodero","sequence":"first","affiliation":[{"name":"Department of Immunology, Harvard Medical School, Boston, MA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1943-4664","authenticated-orcid":true,"given":"Elisa","family":"Cintado","sequence":"additional","affiliation":[{"name":"Cajal Institute, Translational Neuroscience Department, Consejo Superior de Investigaciones Cient\u00edficas, Madrid, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7619-0662","authenticated-orcid":true,"given":"Alec J.","family":"Walker","sequence":"additional","affiliation":[{"name":"F. 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