{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T07:36:53Z","timestamp":1792136213918,"version":"4.4.0"},"reference-count":101,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"110","content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Sci. Immunol."],"published-print":{"date-parts":[[2025,8,29]]},"abstract":"<jats:p>\n                    Adenoviral (Ad) vectors and mRNA vaccines exhibit distinct patterns of immune responses and reactogenicity, but underpinning mechanisms remain unclear. We longitudinally compared homologous ChAdOx1 nCoV-19 and BNT162b2 vaccination, focusing on cytokine-responsive innate-like lymphocytes\u2014mucosal-associated invariant T (MAIT) cells and V\u03b42\n                    <jats:sup>+<\/jats:sup>\n                    \u03b3\u03b4 T cells\u2014which sense and tune innate-adaptive cross-talk. Ad priming elicited robust type I interferon (IFN)\u2013mediated innate-like T cell activation, augmenting T cell responses (innate-to-adaptive signaling), which was dampened at boost by antivector immunity. Conversely, mRNA boosting enhanced innate-like responses, driven by prime-induced spike-specific memory T cell\u2013derived IFN-\u03b3 (adaptive-to-innate signaling). Extending the dosing interval dampened inflammation at boost because of waning T cell memory. In a separate vaccine trial, preboost spike-specific T cells predicted severe mRNA reactogenicity regardless of the priming platform or interval. Overall, bidirectional innate-like and adaptive cross-talk, and IFN-\u03b3\u2013licensed innate-like T cells, orchestrate interval-dependent early vaccine responses, suggesting modifiable targets for safer, more effective regimens.\n                  <\/jats:p>","DOI":"10.1126\/sciimmunol.adu3337","type":"journal-article","created":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T17:58:11Z","timestamp":1756490291000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":14,"title":["MAIT and other innate-like T cells integrate adaptive immune responses to modulate interval-dependent reactogenicity to mRNA vaccines"],"prefix":"10.1126","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6837-8881","authenticated-orcid":true,"given":"Ali","family":"Amini","sequence":"first","affiliation":[{"name":"Translational Gastroenterology and Liver Unit, Nuffield Department of Medicine \u2013 Experimental Medicine, University of 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