{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T02:34:54Z","timestamp":1790217294902,"version":"4.1.0"},"reference-count":91,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"112","content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Sci. Immunol."],"published-print":{"date-parts":[[2025,10,17]]},"abstract":"<jats:p>\n                    Germinal centers (GCs) are key sites for antibody diversification and affinity maturation. SARS-CoV-2 messenger RNA (mRNA) vaccines elicit robust GC B cell responses in humans, but how these responses influence the breadth of immunity against viral variants remains unclear. We analyzed GC B cell responses in nine healthy adults after mRNA booster immunization. We show that 77.8% of the B cell clones in the GC expressed representative monoclonal antibodies (mAbs) recognizing the spike protein, with 37.8% of these targeting the receptor binding domain (RBD). One RBD-targeting mAb, mAb-52, neutralized all tested SARS-CoV-2 strains, including the recent XEC variant. mAb-52 used the\n                    <jats:italic toggle=\"yes\">IGHV3-66<\/jats:italic>\n                    public clonotype, protected hamsters challenged against the EG.5.1 variant, and targeted the class I\/II RBD epitope, closely mimicking the binding footprint of ACE2. Its broad reactivity was driven by extensive somatic hypermutation, underscoring the critical role of GC reactions in shaping cross-variant B cell immunity after SARS-CoV-2 booster vaccination.\n                  <\/jats:p>","DOI":"10.1126\/sciimmunol.adu4107","type":"journal-article","created":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T17:59:14Z","timestamp":1760119154000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":13,"title":["Germinal center\u2013mediated broadening of B cell responses to SARS-CoV-2 booster immunization"],"prefix":"10.1126","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5131-4518","authenticated-orcid":true,"given":"Sameer Kumar","family":"Malladi","sequence":"first","affiliation":[{"name":"Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, 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