{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T00:53:36Z","timestamp":1790124816898,"version":"4.0.1"},"reference-count":72,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"108","content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Sci. Immunol."],"published-print":{"date-parts":[[2025,6,20]]},"abstract":"<jats:p>\n                    Regulatory T cells (T\n                    <jats:sub>reg<\/jats:sub>\n                    cells) are critical regulators of adaptive immunity and the pathophysiology of antitumoral immunity. T\n                    <jats:sub>reg<\/jats:sub>\n                    cells are both generated during thymic development and induced from peripheral conventional T cells. How these distinct pathways contribute to the homeostasis of circulating T\n                    <jats:sub>reg<\/jats:sub>\n                    cells in health and disease remains unclear. We addressed this question using multiple fate-mapping mouse systems and modeling. Naive and effector\/memory (EM) T\n                    <jats:sub>reg<\/jats:sub>\n                    cells exhibit distinct dynamics but are both continuously replenished by de novo generation throughout life. The predominant precursors of circulating EM T\n                    <jats:sub>reg<\/jats:sub>\n                    cells are naive thymic T\n                    <jats:sub>reg<\/jats:sub>\n                    cells and not conventional T cells, a process driven by self rather than foreign antigen recognition. Using the same fate reporters and three tumor models, we demonstrate that infiltrating T\n                    <jats:sub>reg<\/jats:sub>\n                    cells specifically derive from preexisting EM T\n                    <jats:sub>reg<\/jats:sub>\n                    cells. In summary, we define a linear ontogeny of T\n                    <jats:sub>reg<\/jats:sub>\n                    cells from the thymus to EM, driven by self-antigen recognition, that then gives rise to tumor-infiltrating T\n                    <jats:sub>reg<\/jats:sub>\n                    cells.\n                  <\/jats:p>","DOI":"10.1126\/sciimmunol.adu7341","type":"journal-article","created":{"date-parts":[[2025,6,20]],"date-time":"2025-06-20T13:58:17Z","timestamp":1750427897000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":6,"title":["A linear ontogeny accounts for the development of naive, memory, and tumor-infiltrating regulatory T cells in mice"],"prefix":"10.1126","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6137-8718","authenticated-orcid":true,"given":"Sanmoy","family":"Pathak","sequence":"first","affiliation":[{"name":"Institute of Immunity and Transplantation, Division of Infection and 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