{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T20:34:17Z","timestamp":1791318857102,"version":"4.3.1"},"reference-count":93,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"118","license":[{"start":{"date-parts":[[2027,4,10]],"date-time":"2027-04-10T00:00:00Z","timestamp":1807315200000},"content-version":"vor","delay-in-days":365,"URL":"https:\/\/www.science.org\/content\/page\/science-licenses-journal-article-reuse"}],"funder":[{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["DGE 1752814"],"award-info":[{"award-number":["DGE 1752814"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["NIH R01-CA-270790"],"award-info":[{"award-number":["NIH R01-CA-270790"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["1DP2CA247830-01"],"award-info":[{"award-number":["1DP2CA247830-01"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["NIH-RO1-AI51321"],"award-info":[{"award-number":["NIH-RO1-AI51321"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000011","name":"Howard Hughes Medical Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000011","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000884","name":"Cancer Research Institute","doi-asserted-by":"publisher","award":["CRI3984"],"award-info":[{"award-number":["CRI3984"]}],"id":[{"id":"10.13039\/100000884","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000900","name":"California Institute for Regenerative Medicine","doi-asserted-by":"publisher","award":["EDUC4-12790"],"award-info":[{"award-number":["EDUC4-12790"]}],"id":[{"id":"10.13039\/100000900","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005564","name":"Gilead Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005564","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014807","name":"Cancer Research Coordinating Committee","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014807","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Berkeley Center for Research and Education on Aging"}],"content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Sci. Immunol."],"published-print":{"date-parts":[[2026,4,10]]},"abstract":"<jats:p>\n                    Cancer cells frequently lose major histocompatibility complex class I (MHC I) to evade CD8 T cell recognition. Natural killer (NK) cells are poised to target MHC I\u2013deficient cancer cells, but MHC I loss alone is often insufficient to unleash fully effective NK cell responses. Here, we show that selective intratumoral (IT) ablation of regulatory T cells (T\n                    <jats:sub>reg<\/jats:sub>\n                    cells) elicited potent antitumor NK cell responses that controlled MHC I\u2013deficient and even MHC I\n                    <jats:sup>+<\/jats:sup>\n                    cancers that expressed NKG2D ligands. T\n                    <jats:sub>reg<\/jats:sub>\n                    cells controlled the activation, maturation, and antitumor cytotoxic activity of NK cells within the tumor microenvironment. Mechanistically, depletion of IT-T\n                    <jats:sub>reg<\/jats:sub>\n                    cells relieved the inhibition of cDC2-dependent induction of IL-2 production by conventional CD4 T cells that was necessary for NK cell activation. Systemically administered antibodies that selectively depleted IT-T\n                    <jats:sub>reg<\/jats:sub>\n                    cells similarly empowered NK cell\u2013dependent tumor control. These findings expand the breadth of T\n                    <jats:sub>reg<\/jats:sub>\n                    cell\u2013mediated cancer immunosuppression to encompass antitumor NK cells and suggest that therapeutic targeting of T\n                    <jats:sub>reg<\/jats:sub>\n                    cells in tumors can control CD8 T cell\u2013resistant cancers.\n                  <\/jats:p>","DOI":"10.1126\/sciimmunol.adx4411","type":"journal-article","created":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T18:01:58Z","timestamp":1775844118000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":3,"title":["Intratumoral T\n                    <sub>reg<\/sub>\n                    cell ablation elicits NK cell\u2013mediated control of CD8 T cell\u2013resistant tumors"],"prefix":"10.1126","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3199-9422","authenticated-orcid":true,"given":"Chenyu","family":"Zhang","sequence":"first","affiliation":[{"name":"Division of Immunology and Molecular Medicine, Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-7148-9375","authenticated-orcid":true,"given":"Charles","family":"Chien","sequence":"additional","affiliation":[{"name":"Department of Electrical Engineering and Computer Sciences, University of California, Berkeley, Berkeley, CA 94720, USA."},{"name":"Center for Computational Biology, University of California, Berkeley, Berkeley, CA 94720, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Egl\u0117","family":"Jurgaityt\u0117","sequence":"additional","affiliation":[{"name":"Division of Immunology and Molecular Medicine, Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-4613-8931","authenticated-orcid":true,"given":"Koharu","family":"Sakiyama","sequence":"additional","affiliation":[{"name":"Division of Immunology and Molecular Medicine, Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-5444-5036","authenticated-orcid":true,"given":"Alissa","family":"Bockman","sequence":"additional","affiliation":[{"name":"Division of Immunology and Molecular Medicine, Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1340-1968","authenticated-orcid":true,"given":"Yeara","family":"Jo","sequence":"additional","affiliation":[{"name":"Division of Immunology and Molecular Medicine, Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-8584-856X","authenticated-orcid":true,"given":"Seungwon","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Immunology and Molecular Medicine, Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5278-6939","authenticated-orcid":true,"given":"Stephanie","family":"Silveria","sequence":"additional","affiliation":[{"name":"Division of Immunology and Molecular Medicine, Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2265-2486","authenticated-orcid":true,"given":"Elizabeth","family":"Andrews","sequence":"additional","affiliation":[{"name":"Division of Immunology and Molecular Medicine, Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8893-7839","authenticated-orcid":true,"given":"Abigail","family":"Mende","sequence":"additional","affiliation":[{"name":"Division of Immunology and Molecular Medicine, Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lily","family":"Zhang","sequence":"additional","affiliation":[{"name":"Division of Immunology and Molecular Medicine, Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. Christopher","family":"Garcia","sequence":"additional","affiliation":[{"name":"Department of Molecular and Cellular Physiology and Howard Hughes Medical Institute, Stanford University School of Medicine, Palo Alto, CA 94305, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5095-6009","authenticated-orcid":true,"given":"Allon","family":"Wagner","sequence":"additional","affiliation":[{"name":"Division of Immunology and Molecular Medicine, Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA."},{"name":"Department of Electrical Engineering and Computer Sciences, University of California, Berkeley, Berkeley, CA 94720, USA."},{"name":"Center for Computational Biology, University of California, Berkeley, Berkeley, CA 94720, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1479-9840","authenticated-orcid":true,"given":"Michel","family":"DuPage","sequence":"additional","affiliation":[{"name":"Division of Immunology and Molecular Medicine, Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1257-8649","authenticated-orcid":true,"given":"David","family":"Raulet","sequence":"additional","affiliation":[{"name":"Division of Immunology and Molecular Medicine, Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.636568"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2015.12.007"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2014.12.033"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.10.001"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-01062-w"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2020.03.017"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1604958"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1198687"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2018.01.004"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI74337"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-018-0132-0"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.aaz2738"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2200568119"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2023.01.004"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2023.02.014"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.163.10.5211"},{"key":"e_1_3_2_18_2","first-page":"3128","article-title":"Tumor rejection by in vivo administration of anti-CD25 (interleukin-2 receptor alpha) monoclonal antibody","volume":"59","author":"Onizuka S.","year":"1999","unstructured":"S. Onizuka, I. Tawara, J. Shimizu, S. Sakaguchi, T. Fujita, E. Nakayama, Tumor rejection by in vivo administration of anti-CD25 (interleukin-2 receptor alpha) monoclonal antibody. Cancer Res. 59, 3128\u20133133 (1999).","journal-title":"Cancer Res."},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20130579"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1158\/2326-6066.CIR-13-0013"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni1428"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20061852"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2004.04.003"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20122462"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2009.08.023"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20122248"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.2006.00445.x"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.180.7.4679"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature16169"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20122571"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2008.02.016"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2004.05.003"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-032712-095951"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1038\/77793"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1038\/35093109"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.161.7.3501"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0952-7915(03)00099-2"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri1413"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.172.8.4676"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1160062"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1002\/1521-4141(200006)30:6<1538::AID-IMMU1538>3.0.CO;2-X"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2014.12.024"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2014.09.007"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2019.02.005"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-018-0085-8"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1038\/7403"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20011149"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2003.10.012"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20112675"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1164206"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-022-04866-z"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng1180"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0506580102"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20090525"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-18-1119"},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2016.10.032"},{"key":"e_1_3_2_57_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12935-020-01418-1"},{"key":"e_1_3_2_58_2","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.32919"},{"key":"e_1_3_2_59_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.191.11.1895"},{"key":"e_1_3_2_60_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1155209"},{"key":"e_1_3_2_61_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2023.06.003"},{"key":"e_1_3_2_62_2","doi-asserted-by":"publisher","DOI":"10.1111\/imm.13058"},{"key":"e_1_3_2_63_2","doi-asserted-by":"crossref","unstructured":"A. Bockman B. Gittins C. Zhang J. Hung M. M. Ayala D. S. Axe B. M. Weist M. D. Page Intratumoral Treg ablation is sufficient to mediate tumor control systemically without autoimmunity. bioRxiv 661765 [Preprint] (2025). https:\/\/doi.org\/10.1101\/2025.06.26.661765.","DOI":"10.1101\/2025.06.26.661765"},{"key":"e_1_3_2_64_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-10-1736"},{"key":"e_1_3_2_65_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2018.05.050"},{"key":"e_1_3_2_66_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2015.08.006"},{"key":"e_1_3_2_67_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1101649"},{"key":"e_1_3_2_68_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2567.2006.02362.x"},{"key":"e_1_3_2_69_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0408197102"},{"key":"e_1_3_2_70_2","doi-asserted-by":"publisher","DOI":"10.1038\/s43018-023-00600-4"},{"key":"e_1_3_2_71_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2023.112219"},{"key":"e_1_3_2_72_2","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-18-0762"},{"key":"e_1_3_2_73_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41592-025-02824-x"},{"key":"e_1_3_2_74_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20082492"},{"key":"e_1_3_2_75_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2300895120"},{"key":"e_1_3_2_76_2","doi-asserted-by":"publisher","DOI":"10.1038\/s43018-022-00447-1"},{"key":"e_1_3_2_77_2","doi-asserted-by":"publisher","DOI":"10.1080\/2162402X.2022.2141007"},{"key":"e_1_3_2_78_2","doi-asserted-by":"publisher","DOI":"10.1158\/2326-6066.CIR-17-0498"},{"key":"e_1_3_2_79_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.175.8.5541"},{"key":"e_1_3_2_80_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20051511"},{"key":"e_1_3_2_81_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-10-1681"},{"key":"e_1_3_2_82_2","doi-asserted-by":"publisher","DOI":"10.1038\/369031a0"},{"key":"e_1_3_2_83_2","first-page":"e51967","article-title":"Orthotopic injection of breast cancer cells into the mammary fat pad of mice to study tumor growth","volume":"96","author":"Kocat\u00fcrk B.","year":"2015","unstructured":"B. Kocat\u00fcrk, H. H. Versteeg, Orthotopic injection of breast cancer cells into the mammary fat pad of mice to study tumor growth. J. Vis. Exp. 96, e51967 (2015).","journal-title":"J. Vis. Exp."},{"key":"e_1_3_2_84_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkv007"},{"key":"e_1_3_2_85_2","doi-asserted-by":"crossref","unstructured":"H. Wickham in Use R! (Springer 2016) pp. 189\u2013201.","DOI":"10.1007\/978-3-319-24277-4_9"},{"key":"e_1_3_2_86_2","unstructured":"K. Slowikowski ggrepel: Automatically position non-overlapping text labels with \u2018ggplot2.\u2019 (2025) https:\/\/CRAN.R-project.org\/package=ggrepel."},{"key":"e_1_3_2_87_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0802439"},{"key":"e_1_3_2_88_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jim.2004.08.008"},{"key":"e_1_3_2_89_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-1759(03)00265-5"},{"key":"e_1_3_2_90_2","doi-asserted-by":"crossref","unstructured":"C. Zhang C. Chien E. Jurgaityt\u0117 K. Sakiyama A. Bockman Y. Jo S. Lee S. Silveria E. Andrews A. Mende L. Zhang K. C. Garcia A. Wagner M. DuPage D. Raulet Intra-tumoral Treg ablation unleashes NK cell-mediated control of CD8 T cell-resistant tumors. bioRxiv 661417 [Preprint] (2025). https:\/\/doi.org\/10.1101\/2025.06.26.661417.","DOI":"10.1101\/2025.06.26.661417"},{"key":"e_1_3_2_91_2","unstructured":"Wagner Lab Berkeley itdt_rna_seq_data GitHub (2025); https:\/\/github.com\/wagnerlab-berkeley\/itdt_rna_seq_data."},{"key":"e_1_3_2_92_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2021.05.045"},{"key":"e_1_3_2_93_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-021-00909-1"},{"key":"e_1_3_2_94_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2024.114855"}],"container-title":["Science Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/sciimmunol.adx4411","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/sciimmunol.adx4411","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T18:02:07Z","timestamp":1775844127000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/sciimmunol.adx4411"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,10]]},"references-count":93,"journal-issue":{"issue":"118","published-print":{"date-parts":[[2026,4,10]]}},"alternative-id":["10.1126\/sciimmunol.adx4411"],"URL":"https:\/\/doi.org\/10.1126\/sciimmunol.adx4411","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2025.06.26.661417","asserted-by":"object"}]},"ISSN":["2470-9468"],"issn-type":[{"value":"2470-9468","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,10]]},"assertion":[{"value":"2025-03-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-25","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-19","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"eadx4411"}}