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Immunol."],"published-print":{"date-parts":[[2026,1,2]]},"abstract":"<jats:p>\n                    Long-lived immunoglobulin E (IgE) responses against innocuous environmental and dietary antigens (Ags) are maintained by an IgG1-dominant memory B cell (MBC) compartment primed for interleukin-4 (IL-4) responsiveness. The plasticity of the MBC compartment destined for IgE class switch recombination remains poorly understood. In this work, we report critical IL-4 and IL-13 dependency for the pathogenic IgE fate of type 2\u2013polarized MBCs in allergy. Initiation of a recall response in the absence of IL-4 and IL-13 signaling diminished the type 2 MBC phenotype in mice and humans. This permitted the emergence of long-lived Ag-specific IgG2c\n                    <jats:sup>+<\/jats:sup>\n                    MBCs in mice. The divergence to a type 1\u2013like response was dependent on interferon-\u03b3 signaling and arose from both unswitched and class-switched Ag-specific B cells in vivo. This reprogrammed fate was sustained even beyond therapeutic intervention, revealing fundamental insights into the plasticity of the allergen-specific recall response.\n                  <\/jats:p>","DOI":"10.1126\/sciimmunol.ady2268","type":"journal-article","created":{"date-parts":[[2026,1,2]],"date-time":"2026-01-02T18:58:28Z","timestamp":1767380308000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":3,"title":["Pathogenic IgE-fated memory B cell responses retain functional plasticity"],"prefix":"10.1126","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0817-6134","authenticated-orcid":true,"given":"Kelly","family":"Bruton","sequence":"first","affiliation":[{"name":"Schroeder Allergy &amp; Immunology Research Institute and Department of Medicine, McMaster University, Hamilton, Ontario, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5025-7459","authenticated-orcid":true,"given":"Allyssa","family":"Phelps","sequence":"additional","affiliation":[{"name":"Schroeder Allergy &amp; Immunology Research Institute and Department of Medicine, McMaster University, Hamilton, Ontario, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0269-6692","authenticated-orcid":true,"given":"Atai","family":"Ariaz","sequence":"additional","affiliation":[{"name":"Schroeder Allergy &amp; Immunology Research Institute and Department of Medicine, McMaster University, Hamilton, Ontario, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5865-8695","authenticated-orcid":true,"given":"Allison","family":"Fang","sequence":"additional","affiliation":[{"name":"Schroeder Allergy &amp; Immunology Research Institute and Department of Medicine, McMaster University, Hamilton, Ontario, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tina D.","family":"Walker","sequence":"additional","affiliation":[{"name":"Schroeder Allergy &amp; Immunology Research Institute and Department of Medicine, McMaster University, Hamilton, Ontario, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianping","family":"Wen","sequence":"additional","affiliation":[{"name":"Schroeder Allergy &amp; Immunology Research Institute and Department of Medicine, McMaster University, Hamilton, Ontario, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-6871-9016","authenticated-orcid":true,"given":"Sharon S.","family":"Khavkine-Binstock","sequence":"additional","affiliation":[{"name":"Schroeder Allergy &amp; Immunology Research Institute and Department of Medicine, McMaster University, Hamilton, Ontario, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-3633-051X","authenticated-orcid":true,"given":"Danielle","family":"Della Libera","sequence":"additional","affiliation":[{"name":"Schroeder Allergy &amp; Immunology Research Institute and Department of Medicine, McMaster University, Hamilton, Ontario, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-9716-7139","authenticated-orcid":true,"given":"Olivia","family":"Mann-Delany","sequence":"additional","affiliation":[{"name":"Schroeder Allergy &amp; Immunology Research Institute and Department of Medicine, McMaster University, Hamilton, Ontario, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1400-5657","authenticated-orcid":true,"given":"Niels Peter H.","family":"Knudsen","sequence":"additional","affiliation":[{"name":"ALK-Abell\u00f3 A\/S, H\u00f8rsholm, Denmark."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siyon","family":"Gadkar","sequence":"additional","affiliation":[{"name":"Schroeder Allergy &amp; Immunology Research Institute and Department of Medicine, McMaster University, Hamilton, Ontario, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-3059-2070","authenticated-orcid":true,"given":"Emily","family":"Grydziuszko","sequence":"additional","affiliation":[{"name":"Schroeder Allergy &amp; Immunology Research Institute and Department of Medicine, McMaster University, Hamilton, Ontario, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8909-5039","authenticated-orcid":true,"given":"Joshua F. 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