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We found that\n                    <jats:italic toggle=\"yes\">Slc7a11<\/jats:italic>\n                    -expressing IRMs preserve \u03b2 cell redox homeostasis and insulin secretion, both at baseline and under stress. These findings position IRMs as specialized immune sentinels in the endocrine pancreas and identify SLC7A11 as a key macrophage-intrinsic safeguard against oxidative stress, with broad implications for islet resilience and metabolic health.\n                  <\/jats:p>","DOI":"10.1126\/sciimmunol.adz5181","type":"journal-article","created":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T18:59:21Z","timestamp":1763146761000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":17,"title":["An islet-resident macrophage antioxidant program preserves \u03b2 cell physiology"],"prefix":"10.1126","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2059-6510","authenticated-orcid":true,"given":"Am\u00e9lie","family":"Grosjean","sequence":"first","affiliation":[{"name":"Institut Necker Enfants Malades (INEM), INSERM U1151\u2013CNRS UMRS 8253, IMMEDIAB Laboratory, Universit\u00e9 Paris Cit\u00e9, 75015 Paris, France."},{"name":"Centre de Recherche des Cordeliers, INSERM, IMMEDIAB Laboratory, Sorbonne Universit\u00e9, Universit\u00e9 de Paris, 75006 Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-9528-9238","authenticated-orcid":true,"given":"Aude","family":"Jalon","sequence":"additional","affiliation":[{"name":"Institut Necker Enfants Malades (INEM), INSERM U1151\u2013CNRS UMRS 8253, IMMEDIAB Laboratory, Universit\u00e9 Paris Cit\u00e9, 75015 Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Leveau","sequence":"additional","affiliation":[{"name":"Institut Necker Enfants Malades (INEM), INSERM U1151\u2013CNRS UMRS 8253, IMMEDIAB Laboratory, Universit\u00e9 Paris Cit\u00e9, 75015 Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0418-1107","authenticated-orcid":true,"given":"Marc","family":"Diedisheim","sequence":"additional","affiliation":[{"name":"Institut Necker Enfants Malades (INEM), INSERM U1151\u2013CNRS UMRS 8253, IMMEDIAB Laboratory, Universit\u00e9 Paris Cit\u00e9, 75015 Paris, France."},{"name":"Diab\u00e9tologie, Clinique Saint Gatien Alliance (NCT+), 37540 Saint-Cyr-sur-Loire, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7804-0131","authenticated-orcid":true,"given":"David Alejandro","family":"Bejarano","sequence":"additional","affiliation":[{"name":"Quantitative Systems Biology, Life &amp; 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