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Immunol."],"published-print":{"date-parts":[[2026,6,19]]},"abstract":"<jats:p>\n                    Autism spectrum disorder (ASD) is a neurodevelopmental disorder shaped by genetic factors such as copy number variations (CNVs) and immunological factors such as maternal infection. However, most studies on the development of genetic ASD have focused on neurological aspects, and the role of immunity in genetic ASD remains unclear. Here, we demonstrate increased \u03b3\u03b4 T cells in the brains of 15q11-13 duplication (\n                    <jats:italic toggle=\"yes\">15q dup<\/jats:italic>\n                    ) mice, which model a common CNV associated with ASD. Elevated CXCL16 in the brains of\n                    <jats:italic toggle=\"yes\">15q dup<\/jats:italic>\n                    mice promoted \u03b3\u03b4 T cell infiltration, specifically of V\u03b36\n                    <jats:sup>+<\/jats:sup>\n                    \u03b3\u03b4 T cells that produce IL-17A. Deletion of V\u03b36\n                    <jats:sup>+<\/jats:sup>\n                    \u03b3\u03b4 T cells throughout development or treatment with neutralizing antibodies against V\u03b36 or IL-17A increased social behavior in\n                    <jats:italic toggle=\"yes\">15q dup<\/jats:italic>\n                    mice. These findings suggest that immune dysregulation contributes to social behavior deficits in\n                    <jats:italic toggle=\"yes\">15q dup<\/jats:italic>\n                    mice, consistent with observations in maternal immune activation models, and may represent a potential target for interventions for ASD-associated differences in social behavior.\n                  <\/jats:p>","DOI":"10.1126\/sciimmunol.adz8466","type":"journal-article","created":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T17:58:23Z","timestamp":1781891903000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":1,"title":["CXCL16-mediated recruitment of \u03b3\u03b4 T cells to the brain reduces sociability in mice"],"prefix":"10.1126","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-5084-9387","authenticated-orcid":true,"given":"Natsumi","family":"Takayama","sequence":"first","affiliation":[{"name":"Division of Allergy and 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Yamamuro, M. Ikehara, Y. Noriyama, M. Okuda, K. Okumura, K. Matsuoka, N. Kashida, R. Ishida, T. Takeda, M. Toritsuka, T. Ochi, T. Miyasaka, Y. Tai, K. Tatsumi, T. Hattori, T. Tanaka, Y. Saito, N. Iwata, M. Makinodan, Oxytocin receptor neurons in the paraventricular thalamus as a nexus for social behaviour and fear. 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