{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T18:07:45Z","timestamp":1788286065109,"version":"build-2803163510"},"reference-count":107,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"117","funder":[{"DOI":"10.13039\/100020581","name":"Fondazione AIRC per la ricerca sul cancro ETS","doi-asserted-by":"publisher","award":["AIRC StartUp Grant 21474 to T.M."],"award-info":[{"award-number":["AIRC StartUp Grant 21474 to T.M."]}],"id":[{"id":"10.13039\/100020581","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020581","name":"Fondazione AIRC per la ricerca sul cancro ETS","doi-asserted-by":"publisher","award":["AIRC IG 26406"],"award-info":[{"award-number":["AIRC IG 26406"]}],"id":[{"id":"10.13039\/100020581","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Sci. Immunol."],"published-print":{"date-parts":[[2026,3,27]]},"abstract":"<jats:p>Lipid accumulation in the tumor microenvironment is a hallmark of solid tumors, with increased palmitate (PA) availability fostering tumor progression. Although PA\u2019s direct effects on cancer cells are well described, its impact on CD8 T cells [cytotoxic T lymphocytes (CTLs)] remains unclear. Here, we show that PA irreversibly impairs CTL mitochondrial metabolism, leading to the loss of effector functions and compromised antitumor immunity. PA-induced mitochondrial dysfunction reduced histone acetylation and chromatin accessibility, suppressing transcription of genes involved in T cell replication and effector programs. We identified sphingosine kinase 2 (SPHK2) as a key mediator of PA-induced dysfunction, with pharmacological inhibition of SPHK2 restoring mitochondrial fitness, rescuing CTL effector function, and promoting antitumor activity. These findings uncover a distinct mechanism by which PA drives immune evasion in tumors and highlight SPHK2 as a potential therapeutic target to enhance T cell\u2013based immunotherapies.<\/jats:p>","DOI":"10.1126\/sciimmunol.aeb1459","type":"journal-article","created":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T18:02:47Z","timestamp":1774634567000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":7,"title":["Palmitate-induced mitochondrial damage restricts histone acetylation in CD8 T cells to impair antitumor immunity"],"prefix":"10.1126","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2141-2365","authenticated-orcid":true,"given":"Silvia","family":"Tiberti","sequence":"first","affiliation":[{"name":"Department of Experimental Oncology, Istituto Europeo di Oncologia IRCCS, Milan, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Gennari","sequence":"additional","affiliation":[{"name":"Department of Molecular Biotechnology and Health Sciences, University of Turin, Turin, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-5897-8165","authenticated-orcid":true,"given":"Martina","family":"Romeo","sequence":"additional","affiliation":[{"name":"Department of Experimental Oncology, Istituto Europeo di Oncologia IRCCS, Milan, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6020-0256","authenticated-orcid":true,"given":"Ilir","family":"Sheraj","sequence":"additional","affiliation":[{"name":"Centre for Genomic Regulation, Barcelona, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3501-1802","authenticated-orcid":true,"given":"Mohamed Faisal","family":"Kassir","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Hollings Cancer Center, Medical University of South Carolina, Charleston, SC, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3422-3627","authenticated-orcid":true,"given":"Juan","family":"Fern\u00e1ndez-Garc\u00eda","sequence":"additional","affiliation":[{"name":"Laboratory of Cellular Metabolism and Metabolic Regulation, VIB Center for Cancer Biology, VIB, Leuven, Belgium."},{"name":"Laboratory of Cellular Metabolism and Metabolic Regulation, Department of Oncology, KU Leuven and Leuven Cancer Institute (LKI), Leuven, Belgium."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9494-6865","authenticated-orcid":true,"given":"Carina B.","family":"Nava Lauson","sequence":"additional","affiliation":[{"name":"Department of Experimental Oncology, Istituto Europeo di Oncologia IRCCS, Milan, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7267-1079","authenticated-orcid":true,"given":"Roberta","family":"Noberini","sequence":"additional","affiliation":[{"name":"Department of Experimental Oncology, Istituto Europeo di Oncologia IRCCS, Milan, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlotta","family":"Catozzi","sequence":"additional","affiliation":[{"name":"Department of Experimental Oncology, Istituto Europeo di Oncologia IRCCS, Milan, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5653-3741","authenticated-orcid":true,"given":"Tiziano","family":"Dallavilla","sequence":"additional","affiliation":[{"name":"Department of Experimental Oncology, Istituto Europeo di Oncologia IRCCS, Milan, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-1934-9644","authenticated-orcid":true,"given":"Mattia","family":"Ballerini","sequence":"additional","affiliation":[{"name":"Department of Experimental Oncology, Istituto Europeo di Oncologia IRCCS, Milan, Italy."},{"name":"Department of Electronics, Information, and Bioengineering, Politecnico di Milano, Milan, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4523-5666","authenticated-orcid":true,"given":"Alessia","family":"Loffreda","sequence":"additional","affiliation":[{"name":"Experimental Imaging Center, IRCCS San Raffaele Scientific Institute, Milan, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4435-812X","authenticated-orcid":true,"given":"Simona G.","family":"Codreanu","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Center for Innovative Technology, Vanderbilt University, Nashville, TN, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2346-230X","authenticated-orcid":true,"given":"Stacy D.","family":"Sherrod","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Center for Innovative Technology, Vanderbilt University, Nashville, TN, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9266-145X","authenticated-orcid":true,"given":"Katrina L.","family":"Leaptrot","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Center for Innovative Technology, Vanderbilt University, Nashville, TN, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7086-1170","authenticated-orcid":true,"given":"Alexandra C.","family":"Schrimpe-Rutledge","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Center for Innovative Technology, Vanderbilt University, Nashville, TN, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8918-6419","authenticated-orcid":true,"given":"John A.","family":"McLean","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Center for Innovative Technology, Vanderbilt University, Nashville, TN, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7503-6364","authenticated-orcid":true,"given":"Martin H.","family":"Schaefer","sequence":"additional","affiliation":[{"name":"Department of Experimental Oncology, Istituto Europeo di Oncologia IRCCS, Milan, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4236-7823","authenticated-orcid":true,"given":"Simona","family":"Rodighiero","sequence":"additional","affiliation":[{"name":"Department of Experimental Oncology, Istituto Europeo di Oncologia IRCCS, Milan, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3556-1265","authenticated-orcid":true,"given":"Tiziana","family":"Bonaldi","sequence":"additional","affiliation":[{"name":"Department of Experimental Oncology, Istituto Europeo di Oncologia IRCCS, Milan, Italy."},{"name":"Department of Oncology and Hematology-Oncology, University of Milan, Milan, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6018-9296","authenticated-orcid":true,"given":"Sarah-Maria","family":"Fendt","sequence":"additional","affiliation":[{"name":"Laboratory of Cellular Metabolism and Metabolic Regulation, VIB Center for Cancer Biology, VIB, Leuven, Belgium."},{"name":"Laboratory of Cellular Metabolism and Metabolic Regulation, Department of Oncology, KU Leuven and Leuven Cancer Institute (LKI), Leuven, Belgium."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1019-5660","authenticated-orcid":true,"given":"Besim","family":"Ogretmen","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Hollings Cancer Center, Medical University of South Carolina, Charleston, SC, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1330-4364","authenticated-orcid":true,"given":"Sara","family":"Sdelci","sequence":"additional","affiliation":[{"name":"Centre for Genomic Regulation, Barcelona, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4670-7656","authenticated-orcid":true,"given":"Luigi","family":"Nezi","sequence":"additional","affiliation":[{"name":"Department of Experimental Oncology, Istituto Europeo di Oncologia IRCCS, Milan, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8552-3625","authenticated-orcid":true,"given":"Teresa","family":"Manzo","sequence":"additional","affiliation":[{"name":"Department of Molecular Biotechnology and Health Sciences, University of Turin, Turin, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-03442-1"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2022.07.012"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.03.023"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.44235"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-04049-2"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.coisb.2021.100401"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2021.04.013"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.trecan.2019.09.007"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2023.02.013"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41589-022-01017-3"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2019.08.007"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20191920"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-19-2994"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20210042"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2021.05.003"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-020-0783-5"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/s43018-023-00513-2"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-04075-0"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature20791"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2017.01.008"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0116195"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2068"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2010.09.002"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1067710"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2007.07.010"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2009.06.021"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2016.05.035"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2015.05.014"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1164097"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrm3841"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2016.10.012"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrm.2016.140"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gky224"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1111\/febs.15707"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2017.03.012"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2016.11.009"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2021.03.006"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.51.5.786"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrm3931"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2023.08.021"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2023.03.018"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaf2807"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aae0491"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature22367"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.06.007"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-020-0793-3"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri.2017.146"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri3470"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.15.1.707"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20182009"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2007.07.002"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2021.03.003"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2023.03.022"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrm2329"},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.01.038"},{"key":"e_1_3_2_57_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcb.2011.09.003"},{"key":"e_1_3_2_58_2","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.392"},{"key":"e_1_3_2_59_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1176709"},{"key":"e_1_3_2_60_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2011.05.025"},{"key":"e_1_3_2_61_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2022016112"},{"key":"e_1_3_2_62_2","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.109.163444"},{"key":"e_1_3_2_63_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2016.09.025"},{"key":"e_1_3_2_64_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI125297"},{"key":"e_1_3_2_65_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-024-07787-1"},{"key":"e_1_3_2_66_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2021.109076"},{"key":"e_1_3_2_67_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1535-6108(03)00309-X"},{"key":"e_1_3_2_68_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.gpb.2022.08.004"},{"key":"e_1_3_2_69_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2021.02.015"},{"key":"e_1_3_2_70_2","doi-asserted-by":"publisher","DOI":"10.1111\/imr.12655"},{"key":"e_1_3_2_71_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2017.08.004"},{"key":"e_1_3_2_72_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M502207200"},{"key":"e_1_3_2_73_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2021.12.012"},{"key":"e_1_3_2_74_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbalip.2008.05.004"},{"key":"e_1_3_2_75_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-022-01199-1"},{"key":"e_1_3_2_76_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2022.03.013"},{"key":"e_1_3_2_77_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2021.03.002"},{"key":"e_1_3_2_78_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M504507200"},{"key":"e_1_3_2_79_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddx046"},{"key":"e_1_3_2_80_2","first-page":"tw407-TW407","article-title":"Sphingosine kinase 2 triggers cell death","volume":"2003","year":"2003","unstructured":"Sphingosine kinase 2 triggers cell death. Sci. STKE 2003, tw407-TW407 (2003).","journal-title":"Sci. STKE"},{"key":"e_1_3_2_81_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10637-010-9452-0"},{"key":"e_1_3_2_82_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.prostaglandins.2017.03.006"},{"key":"e_1_3_2_83_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.26604"},{"key":"e_1_3_2_84_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2492"},{"key":"e_1_3_2_85_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12876-015-0404-1"},{"key":"e_1_3_2_86_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-017-0027-2"},{"key":"e_1_3_2_87_2","doi-asserted-by":"publisher","DOI":"10.1111\/cas.13766"},{"key":"e_1_3_2_88_2","doi-asserted-by":"publisher","DOI":"10.1038\/ctg.2014.5"},{"key":"e_1_3_2_89_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-019-0589-5"},{"key":"e_1_3_2_90_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2021.3520"},{"key":"e_1_3_2_91_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms15725"},{"key":"e_1_3_2_92_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.trecan.2023.06.003"},{"key":"e_1_3_2_93_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.11.009"},{"key":"e_1_3_2_94_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2005.04.023"},{"key":"e_1_3_2_95_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btw313"},{"key":"e_1_3_2_96_2","doi-asserted-by":"publisher","DOI":"10.1002\/0471142727.mb2129s109"},{"key":"e_1_3_2_97_2","doi-asserted-by":"publisher","DOI":"10.1002\/0471142735.im0316bs113"},{"key":"e_1_3_2_98_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.165.5.2651"},{"key":"e_1_3_2_99_2","doi-asserted-by":"publisher","DOI":"10.1016\/bs.mie.2016.09.036"},{"key":"e_1_3_2_100_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13148-021-01120-7"},{"key":"e_1_3_2_101_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41556-022-00974-0"},{"key":"e_1_3_2_102_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-020-0839-y"},{"key":"e_1_3_2_103_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.01.010"},{"key":"e_1_3_2_104_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.09.028"},{"key":"e_1_3_2_105_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aad0095"},{"key":"e_1_3_2_106_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-12159-9"},{"key":"e_1_3_2_107_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-023-02978-x"},{"key":"e_1_3_2_108_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-0969-x"}],"container-title":["Science Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/sciimmunol.aeb1459","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T18:02:50Z","timestamp":1774634570000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/sciimmunol.aeb1459"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,27]]},"references-count":107,"journal-issue":{"issue":"117","published-print":{"date-parts":[[2026,3,27]]}},"alternative-id":["10.1126\/sciimmunol.aeb1459"],"URL":"https:\/\/doi.org\/10.1126\/sciimmunol.aeb1459","relation":{},"ISSN":["2470-9468"],"issn-type":[{"value":"2470-9468","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,27]]},"assertion":[{"value":"2025-08-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-05","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-27","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"eaeb1459"}}