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GC modified pyruvate kinase M2 (PKM2) through posttranslational glutaconylation at key lysine residues Lys\n                    <jats:sup>336<\/jats:sup>\n                    (K336) and K337. This modification reinforced PKM2 dimers, transcriptionally driving metabolic reprogramming and reinvigorating antitumor CD8 T cells. 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