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Immunol."],"published-print":{"date-parts":[[2026,10,2]]},"abstract":"<jats:p>\n                    Malignant ascites is caused by the peritoneal dissemination of cancer and has a poor prognosis. Here, we performed multiomic analyses on ascites samples from patients with cancer and identified\n                    <jats:italic toggle=\"yes\">RORC<\/jats:italic>\n                    -expressing dendritic cells (\n                    <jats:italic toggle=\"yes\">RORC<\/jats:italic>\n                    DCs) enriched in malignant ascites.\n                    <jats:italic toggle=\"yes\">RORC<\/jats:italic>\n                    DCs expressed\n                    <jats:italic toggle=\"yes\">PIGR<\/jats:italic>\n                    and were transcriptionally similar to murine ROR\u03b3t\n                    <jats:sup>+<\/jats:sup>\n                    DCs\/Thetis cells implicated in immune tolerance. We devised a high-purity sorting strategy to enable in vitro experiments with patient-derived\n                    <jats:italic toggle=\"yes\">RORC<\/jats:italic>\n                    DCs, which indicated that these cells were phenotypically stable and stimulated T cell proliferation while attenuating\n                    <jats:italic toggle=\"yes\">IFNG<\/jats:italic>\n                    expression. Multiplexed immunofluorescence identified\n                    <jats:italic toggle=\"yes\">RORC<\/jats:italic>\n                    DCs in primary tumors and demonstrated their enrichment in regional lymph node metastases. These results associate human\n                    <jats:italic toggle=\"yes\">RORC<\/jats:italic>\n                    DCs with advanced malignancies and suggest a role for these cells in the tumor microenvironment.\n                  <\/jats:p>","DOI":"10.1126\/sciimmunol.aeb9068","type":"journal-article","created":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T17:58:56Z","timestamp":1790963936000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":0,"title":["Multiomic analysis of malignant ascites defines\n                    <i>RORC<\/i>\n                    -expressing dendritic cells at sites of metastasis"],"prefix":"10.1126","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6030-7192","authenticated-orcid":true,"given":"Steven M.","family":"Blum","sequence":"first","affiliation":[{"name":"Mass General Brigham Cancer Institute, Boston, MA, USA."},{"name":"Center for Immunology and Inflammatory Diseases, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA."},{"name":"Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA."},{"name":"Krantz Family Center for Cancer Research, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA."},{"name":"Harvard Medical School, Boston, MA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-3700-3179","authenticated-orcid":true,"given":"Thomas L.","family":"Chan","sequence":"additional","affiliation":[{"name":"Center for Immunology and Inflammatory Diseases, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA."},{"name":"Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA."},{"name":"Krantz Family Center for Cancer Research, Department of Medicine, Massachusetts General Hospital, Boston, MA, 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M.","year":"2023","unstructured":"J. M. Foster, C. Zhang, S. Rehman, P. Sharma, H. R. Alexander, The contemporary management of peritoneal metastasis: A journey from the cold past of treatment futility to a warm present and a bright future. CA Cancer J. Clin. 73, 49\u201371 (2023).","journal-title":"CA Cancer J. 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