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Immunol."],"published-print":{"date-parts":[[2026,5,29]]},"abstract":"<jats:p>\n                    Selective in vivo reprogramming of cytotoxic effector CD8 T (T\n                    <jats:sub>eff<\/jats:sub>\n                    ) cells holds tremendous promise as a therapeutic tool but has not yet been accomplished. Here, we demonstrate that fractalkine-conjugated mRNA lipid nanoparticles (mRNA-LNPs) can specifically target and deliver mRNA to CX3CR1\n                    <jats:sup>+<\/jats:sup>\n                    T\n                    <jats:sub>eff<\/jats:sub>\n                    cells in vitro and in vivo. In mice, fractalkine-conjugated mRNA-LNPs targeted up to 95% of blood and splenic T\n                    <jats:sub>eff<\/jats:sub>\n                    cells. In addition, delivery of IL-2\u2013encoding mRNA and human CD62L-encoding mRNA to mouse T\n                    <jats:sub>eff<\/jats:sub>\n                    cells enabled robust exogenous IL-2 secretion and CD62L expression. In rhesus macaques, fractalkine-conjugated mRNA-LNPs targeted up to ~100% of peripheral blood T\n                    <jats:sub>eff<\/jats:sub>\n                    cells, and delivery of human CD62L-encoding mRNA enabled cell-surface human CD62L expression on peripheral blood T\n                    <jats:sub>eff<\/jats:sub>\n                    cells and detection of human CD62L\n                    <jats:sup>+<\/jats:sup>\n                    T\n                    <jats:sub>eff<\/jats:sub>\n                    cells in lymphoid tissue. Collectively, these data demonstrate the potential of natural receptor ligand-based targeting of mRNA-LNPs for rapid, efficient, and transient in vivo modification of T\n                    <jats:sub>eff<\/jats:sub>\n                    cells.\n                  <\/jats:p>","DOI":"10.1126\/sciimmunol.aec3436","type":"journal-article","created":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T20:49:29Z","timestamp":1781124569000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":1,"title":["In vivo reprogramming of cytotoxic effector CD8 T cells via fractalkine-conjugated mRNA-LNPs"],"prefix":"10.1126","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2469-8215","authenticated-orcid":true,"given":"Angela R.","family":"Corrigan","sequence":"first","affiliation":[{"name":"Department of Microbiology, University of Pennsylvania, Philadelphia, PA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5738-2834","authenticated-orcid":true,"given":"Shin Foong","family":"Ngiow","sequence":"additional","affiliation":[{"name":"Institute for Immunology and Immune Health, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA."},{"name":"Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA."},{"name":"Parker Institute for Cancer Immunotherapy, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0070-2195","authenticated-orcid":true,"given":"Maura","family":"Statzu","sequence":"additional","affiliation":[{"name":"Division of Microbiology and Immunology, Emory National Primate Research Center, Emory University, Atlanta, GA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-1501-2256","authenticated-orcid":true,"given":"Amie","family":"Albertus","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Pennsylvania, Philadelphia, PA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6665-4865","authenticated-orcid":true,"given":"M. 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