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Immunol."],"published-print":{"date-parts":[[2026,10,2]]},"abstract":"<jats:p>\n                    Many helminth parasites migrate through multiple host organs during infection, but how immune responses are relayed across these tissues is still poorly understood. To investigate the immune aspects of intertissue communication during infection, we established a percutaneous infection model with the tissue-migrating nematode\n                    <jats:italic toggle=\"yes\">Nippostrongylus brasiliensis<\/jats:italic>\n                    . Profiling of the initial cutaneous immune response revealed that dermal \u03b3\u03b4 T cells become activated via an interleukin 1 receptor (IL-1R)\u2013dependent mechanism, engage cell motility\u2013associated transcriptional pathways, and leave the skin after parasite invasion. Inhibition of leukocyte migration prevents the accumulation of IL-17\u2013producing \u03b3\u03b4 T cells in the lungs. Bypassing the skin phase of infection, and thereby preventing dermal \u03b3\u03b4 T cell migration, dampens early IL-17 production in the lungs. This, instead, leads to an enhanced interferon-\u03b3 (IFN-\u03b3) response together with increased lung damage. Collectively, our data highlight a critical skin-lung axis regulating host-parasite interactions and safeguarding lung health.\n                  <\/jats:p>","DOI":"10.1126\/sciimmunol.aec7574","type":"journal-article","created":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T17:58:56Z","timestamp":1790963936000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":0,"title":["Migratory dermal \u03b3\u03b4 T cells determine the balance between lung immunity and tissue damage during helminth infection"],"prefix":"10.1126","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2488-7182","authenticated-orcid":true,"given":"Pedro H.","family":"Papotto","sequence":"first","affiliation":[{"name":"Lydia Becker Institute for Immunology &amp; Infection, Faculty of Biology, Medicine &amp; Health, Manchester Academic Health Science Centre, University of Manchester, Manchester, 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