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Immunol."],"published-print":{"date-parts":[[2026,10,16]]},"abstract":"<jats:p>\n                    Glycans play fundamental roles in T cell biology; however, the glycome landscape of \u03b3\u03b4 T cells remains to be unlocked. Despite the growing importance of \u03b3\u03b4 T cells in host defense, tissue homeostasis, and diseases, the glycosylation mechanisms guiding their activation, commitment, and function remain poorly defined. By performing single-cell RNA sequencing, we revealed that type 3\/\u03b3\u03b4 T17\/interleukin-17A (IL-17A)\u2013committed \u03b3\u03b4 T cells rely on (\n                    <jats:italic toggle=\"yes\">N-acetylglucosaminyltransferase 1<\/jats:italic>\n                    )\n                    <jats:italic toggle=\"yes\">MGAT1<\/jats:italic>\n                    \u2013\n                    <jats:italic toggle=\"yes\">MGAT5<\/jats:italic>\n                    \u2013mediated branched N-glycosylation. We further demonstrated that the absence of branched\n                    <jats:italic toggle=\"yes\">N<\/jats:italic>\n                    -glycans on \u03b3\u03b4 T cells acts as a peripheral signal, driving an IL-17A\u2013pro-inflammatory phenotype, alongside a shift to a V\u03b34\n                    <jats:sup>+<\/jats:sup>\n                    subset and the imprinting of innate-like properties. This altered glycoform of type 3 \u03b3\u03b4 T cells was shown to induce severe psoriasis. \u03b3\u03b4 T cells from patients with autoimmune and inflammatory diseases exhibited a deficiency in branched\n                    <jats:italic toggle=\"yes\">N<\/jats:italic>\n                    -glycans. Glycan supplementation can reprogram \u03b3\u03b4 T cells toward a less-pathogenic state, highlighting\n                    <jats:italic toggle=\"yes\">N<\/jats:italic>\n                    -glycans as a previously unrecognized immune checkpoint for \u03b3\u03b4 T cells.\n                  <\/jats:p>","DOI":"10.1126\/sciimmunol.aec9553","type":"journal-article","created":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T17:58:08Z","timestamp":1792173488000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":0,"title":["Glycome remodeling programs pathogenic \u03b3\u03b4 T17 cell responses in autoimmunity"],"prefix":"10.1126","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7094-0394","authenticated-orcid":true,"given":"Beatriz","family":"Santos-Pereira","sequence":"first","affiliation":[{"name":"Institute for Research and Innovation in Health, University of Porto, Porto, Portugal."},{"name":"Faculty of Medicine, 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