{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T16:53:50Z","timestamp":1792083230872,"version":"4.4.0"},"reference-count":41,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"118","funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01NS045937"],"award-info":[{"award-number":["R01NS045937"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01NS30843"],"award-info":[{"award-number":["R01NS30843"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AI144166"],"award-info":[{"award-number":["R01AI144166"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P01AI073748"],"award-info":[{"award-number":["P01AI073748"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P01AI039671"],"award-info":[{"award-number":["P01AI039671"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P01AI056299"],"award-info":[{"award-number":["P01AI056299"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Institute of Health","award":["5K08AR079007"],"award-info":[{"award-number":["5K08AR079007"]}]}],"content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Sci. Immunol."],"published-print":{"date-parts":[[2026,4,24]]},"abstract":"<jats:p>\n                    T helper 17 (T\n                    <jats:sub>H<\/jats:sub>\n                    17) cells are thought to play an important role in the pathogenesis of many autoimmune disorders, including multiple sclerosis and its animal model, experimental autoimmune encephalomyelitis (EAE). However, recent studies have suggested that interleukin-17 (IL-17) may be dispensable for the induction of EAE. Here, we use an adoptive transfer model of EAE to demonstrate that an adaptive cellular source of IL-17 is absolutely required for the induction of EAE disease. We further show that B cells can regulate the transfer of EAE disease in this context. Transcriptional profiling of T\n                    <jats:sub>H<\/jats:sub>\n                    17 cells in our model suggests that loss of IL-17A\/F in T cells results in a lack of an IL-23 receptor (IL-23R)\u2013driven signaling signature. Our data demonstrate the critical importance of an adaptive immune cellular source of IL-17A and IL-17F to mediate EAE and that IL-17 signaling is required for IL-23\u2013mediated T\n                    <jats:sub>H<\/jats:sub>\n                    17 cell pathogenicity.\n                  <\/jats:p>","DOI":"10.1126\/sciimmunol.aee1481","type":"journal-article","created":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T17:58:11Z","timestamp":1777053491000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":2,"title":["An adaptive cellular source of IL-17A and IL-17F is critical for the induction of experimental autoimmune encephalomyelitis"],"prefix":"10.1126","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5861-0552","authenticated-orcid":true,"given":"Allen W.","family":"Ho","sequence":"first","affiliation":[{"name":"Gene Lay Institute of Immunology and Inflammation, Brigham and Women\u2019s Hospital, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA."},{"name":"Broad Institute of MIT and Harvard, Cambridge, MA, USA."},{"name":"Department of Dermatology, Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, MA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3376-9476","authenticated-orcid":true,"given":"Linglin","family":"Huang","sequence":"additional","affiliation":[{"name":"Gene Lay Institute of Immunology and Inflammation, Brigham and Women\u2019s Hospital, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA."},{"name":"Broad Institute of MIT and Harvard, Cambridge, MA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sumiti","family":"Sandhu","sequence":"additional","affiliation":[{"name":"Gene Lay Institute of Immunology and Inflammation, Brigham and Women\u2019s Hospital, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA."},{"name":"Broad Institute of MIT and Harvard, Cambridge, MA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6458-2490","authenticated-orcid":true,"given":"Sheng","family":"Xiao","sequence":"additional","affiliation":[{"name":"Gene Lay Institute of Immunology and Inflammation, Brigham and Women\u2019s Hospital, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA."},{"name":"Broad Institute of MIT and Harvard, Cambridge, MA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa","family":"Sgodzai","sequence":"additional","affiliation":[{"name":"Gene Lay Institute of Immunology and Inflammation, Brigham and Women\u2019s Hospital, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA."},{"name":"Broad Institute of MIT and Harvard, Cambridge, MA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ella","family":"Ullerich","sequence":"additional","affiliation":[{"name":"Gene Lay Institute of Immunology and Inflammation, Brigham and Women\u2019s Hospital, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA."},{"name":"Broad Institute of MIT and Harvard, Cambridge, MA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajesh K.","family":"Krishnan","sequence":"additional","affiliation":[{"name":"Gene Lay Institute of Immunology and Inflammation, Brigham and Women\u2019s Hospital, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3442-7750","authenticated-orcid":true,"given":"Alexandra","family":"Schnell","sequence":"additional","affiliation":[{"name":"Gene Lay Institute of Immunology and Inflammation, Brigham and Women\u2019s Hospital, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA."},{"name":"Broad Institute of MIT and Harvard, Cambridge, MA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7177-2110","authenticated-orcid":true,"given":"Vijay K.","family":"Kuchroo","sequence":"additional","affiliation":[{"name":"Gene Lay Institute of Immunology and Inflammation, Brigham and Women\u2019s Hospital, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA."},{"name":"Broad Institute of MIT and Harvard, Cambridge, MA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-pathol-011110-130318"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.021908.132710"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2008.070690"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.171.11.6173"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.20001"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.10173"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa062382"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.177.7.4917"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-016-8128-x"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2019.04.006"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.aba9953"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2027"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-019-0521-4"},{"key":"e_1_3_2_15_2","first-page":"61","article-title":"IL-17A 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Haak, A. L. Croxford, K. Kreymborg, F. L. Heppner, S. Pouly, B. Becher, A. Waisman, IL-17A and IL-17F do not contribute vitally to autoimmune neuro-inflammation in mice. J. Clin. Invest. 119, 61\u201369 (2009).","journal-title":"J. Clin. 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