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This pathway of monocyte education was distinct from that in T\n                    <jats:sub>H<\/jats:sub>\n                    1 settings and involved an endogenous bacteria\u2013mediated induction of type I IFN that led to adaptive lymphocyte\u2013dependent IFN-\u03b3 priming of monocytes. These findings reveal an IFN-driven mechanism of monocyte education that enables the host to be simultaneously protected against type 2 infections at barrier sites and type 1 infections in the circulation.\n                  <\/jats:p>","DOI":"10.1126\/sciimmunol.aeh4719","type":"journal-article","created":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T17:58:17Z","timestamp":1787939897000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":0,"title":["Type I IFN\u2013induced IFN-\u03b3 instructs monocyte-mediated systemic bacterial protection during type 2 intestinal helminth infection"],"prefix":"10.1126","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0385-5920","authenticated-orcid":true,"given":"Kelly","family":"Wemyss","sequence":"first","affiliation":[{"name":"Lydia Becker Institute of Immunology and Inflammation Research, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, 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