{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T06:24:50Z","timestamp":1790922290264,"version":"4.1.0"},"reference-count":30,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"25","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sci. Signal."],"published-print":{"date-parts":[[2008,6,24]]},"abstract":"<jats:p>\n            In noncontractile cells, a sustained increase in total cytoplasmic Ca\n            <jats:sup>2+<\/jats:sup>\n            concentration is typically needed to activate the intracellular protein phosphatase calcineurin, leading to dephosphorylation of the transcription factor nuclear factor of activated T cells (NFAT), its nuclear translocation, and induction of gene expression. It remains a mystery exactly how Ca\n            <jats:sup>2+<\/jats:sup>\n            -dependent signaling pathways, such as that mediated by calcineurin-NFAT, are regulated in contracting cardiac myocytes given the highly specialized manner in which Ca\n            <jats:sup>2+<\/jats:sup>\n            concentration rhythmically cycles in excitation-contraction coupling. Here, we critically review evidence that supports the hypothesis that calcineurin-NFAT signaling is regulated by contractile Ca\n            <jats:sup>2+<\/jats:sup>\n            transients in cardiac myocytes.\n          <\/jats:p>","DOI":"10.1126\/scisignal.125pe31","type":"journal-article","created":{"date-parts":[[2008,9,24]],"date-time":"2008-09-24T00:02:35Z","timestamp":1222214555000},"source":"Crossref","is-referenced-by-count":84,"title":["Does Contractile Ca\n            <sup>2+<\/sup>\n            Control Calcineurin-NFAT Signaling and Pathological Hypertrophy in Cardiac Myocytes?"],"prefix":"10.1126","volume":"1","author":[{"given":"Steven R.","family":"Houser","sequence":"first","affiliation":[{"name":"Department of Physiology, Temple University School of Medicine, 3400 North Broad Street, Philadelphia, PA 19140, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffery D.","family":"Molkentin","sequence":"additional","affiliation":[{"name":"Cincinnati Children\u2019s Hospital Medical Center, Department of Pediatrics, University of Cincinnati, 3333 Burnet Avenue, Cincinnati, OH 45229, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_1_1_2","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1341.008"},{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI24178"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/386855a0"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/31960"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/cdg381"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2004.07.121"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81573-1"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000109415.17511.18"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0712316105"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.97.3.1196"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2003.053579"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.275.3.1855"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200103020"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e05-08-0780"},{"key":"e_1_3_1_15_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00195.2007"},{"key":"e_1_3_1_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-6363(01)00487-4"},{"key":"e_1_3_1_17_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.103.1.140"},{"key":"e_1_3_1_18_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI31060"},{"key":"e_1_3_1_19_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4020-6191-2_20"},{"key":"e_1_3_1_20_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.103.5.670"},{"key":"e_1_3_1_21_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0503465103"},{"key":"e_1_3_1_22_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1988.sp017372"},{"key":"e_1_3_1_23_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2002.020552"},{"key":"e_1_3_1_24_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-005-5353-3"},{"key":"e_1_3_1_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0012-3692(15)31443-4"},{"key":"e_1_3_1_26_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000012223.86441.A1"},{"key":"e_1_3_1_27_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000033970.22130.93"},{"key":"e_1_3_1_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2006.01.018"},{"key":"e_1_3_1_29_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI27374"},{"key":"e_1_3_1_30_2","doi-asserted-by":"publisher","DOI":"10.1080\/07853890410018899"}],"container-title":["Science Signaling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/scisignal.125pe31","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,16]],"date-time":"2024-01-16T11:07:55Z","timestamp":1705403275000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/scisignal.125pe31"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,6,24]]},"references-count":30,"journal-issue":{"issue":"25","published-print":{"date-parts":[[2008,6,24]]}},"alternative-id":["10.1126\/scisignal.125pe31"],"URL":"https:\/\/doi.org\/10.1126\/scisignal.125pe31","relation":{},"ISSN":["1945-0877","1937-9145"],"issn-type":[{"value":"1945-0877","type":"print"},{"value":"1937-9145","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,6,24]]}}}